miRNA影响苯并[a]芘诱发毒性的机制研究进展

Advances in Mechanism Study of miRNA on Toxicity Induced by Benzo[a]Pyrene

苯并[a]芘(B[a]P)作为多环芳烃类化合物(PAHs)中毒性最大的一种强致癌物,广泛存在于高温加工食品中。流行病学研究表明,B[a]P与许多疾病的发生、发展密切相关。微小RNA(miRNA)是单链(17~25个核苷酸)非编码RNA,通过mRNA降解或翻译抑制负调控特定的靶基因。miRNA在B[a]P诱发致癌性、生殖毒性、神经毒性等过程中发挥重要作用。作者根据现有的研究对miRNA在B[a]P产生毒性过程中的作用机制进行综述,旨在深入揭示B[a]P的毒理机制并为其食品安全控制提供新的研究思路。

Benzo[a]Pyrene(B[a]P),as a polycyclic aromatic hydrocarbon(PAHs)with the highest toxicity and a potent carcinogen,widely exisTSin the high-temperature processed food.A large number of epidemiological studies have shown that B[a]P is closely related to the occurrence and development of many diseases.MicroRNA(miRNA)is a short(17~25 nucleotides)non-coding RNAs,which negatively regulates specific target genes through mRNA degradation or translation inhibition.MiRNA plays an important role in the process of B[a]P-induced carcinogenicity,reproductive toxicity,neurotoxicity,and other processes.Based on the existing findings,this study reviews the mechanism of miRNA in the toxicity process induced by B[a]P,aiming to further reveal the toxicological mechanism of B[a]P and to provide new research directions and ideas for the disease prevention and food safety control.