调节性T细胞过继治疗在自身免疫性疾病中的研究进展

Research advances in Treg cell adoptive therapy in autoimmune diseases

相比传统糖皮质激素联合氨甲蝶呤、硫唑嘌呤等改善自身免疫疾病方案治疗周期长、不良反应程度重的特点,近年来研究显示恢复或逆转调节性T细胞(regulatory T cells,Treg)相关的免疫失衡能有效治疗自身免疫性疾病,在自身免疫性疾病的临床应用方面具有巨大的潜力。本文就近年来Treg细胞过继治疗在常见自身免疫性疾病中的研究进展进行概述。

The long treatment period and severe side effects are the disadvantages of traditional glucocorticoids combined with methotrexate,azathioprine and other methods for the treatment of autoimmune diseases.In recent years,studies have shown that restoring or reversing Treg-related immune imbalance can effectively treat autoimmune diseases,which has great potential for clinical application in autoimmune diseases.This review summarizes the research progress of adoptive therapy of Treg cells in the treatment of common autoimmune diseases in recent years.