磷酸奥司他韦关键中间体的合成工艺优化研究

The Research on Key Intermediates of Oseltamivir Phosphate Synthesis Process Optimization

研究磷酸奥司他韦关键中间体的合成工艺,并对工艺参数进行了优化。以环氧化合物为起始物料,对甲苯的体积、氯化镁的用量、反应温度、淬灭温度进行了筛选,对其稳定性进行了研究,优化后的工艺路线反应条件温和,生产过程安全,适合工业化生产。

In this paper,the synthesis of key intermediates of oseltamivir phosphate and the process parameters was optimized.Using epoxy compound as raw materia,the volume of toluene,the amount of magnesium chloride,reaction temperature and quenching temperature were studied,and the stability of intermediate was investigated.The optimized process has the advantages including mild reaction conditions,safety production process and suitable for large-scale preparation.