摘要
研究磷酸奥司他韦关键中间体的合成工艺,并对工艺参数进行了优化。以环氧化合物为起始物料,对甲苯的体积、氯化镁的用量、反应温度、淬灭温度进行了筛选,对其稳定性进行了研究,优化后的工艺路线反应条件温和,生产过程安全,适合工业化生产。
In this paper,the synthesis of key intermediates of oseltamivir phosphate and the process parameters was optimized.Using epoxy compound as raw materia,the volume of toluene,the amount of magnesium chloride,reaction temperature and quenching temperature were studied,and the stability of intermediate was investigated.The optimized process has the advantages including mild reaction conditions,safety production process and suitable for large-scale preparation.
作者
李佳俐
田家林
王统贵
张武松
李彩花
吴硕
张心宇
Li Jiali;Tian Jialin;Wang Tonggui;Zhang Wusong;Li Caihua;Wu Shuo;Zhang Xinyu(Hunan Food and Drug Vocational College,Changsha 410000;Hunan Ouya Pharmaceutical Company,Changsha 410000,China)
出处
《广东化工》
CAS
2023年第14期21-24,共4页
Guangdong Chemical Industry
关键词
磷酸奥司他韦
中间体
合成
工艺优化
oseltamivir phosphate
intermediate
synthesis
process optimization