PET/CT超级迭代技术诊断孤立性肺结节

PET/CT super-iterative techniquesfor diagnosing solitary pulmonary nodules

目的观察PET/CT超级迭代技术诊断良、恶性孤立性肺结节(SPN)、评估肿瘤侵袭程度及Ki-67表达的价值。方法纳入53例经病理确诊并接受PET/CT检查的恶性SPN患者(恶性组)及53例良性SPN患者(良性组),采用超级迭代技术获取病灶最大标准摄取值(SUV_(max))及平均标准摄取值(SUV_(mean)),以受试者工作特征曲线分析PET/CT参数判断良、恶性SPN的价值;比较不同侵袭程度及表达Ki-67情况的恶性SPN PET/CT参数差异,以Spearman相关性分析评价PET/CT参数与恶性SPN侵袭程度及Ki-67表达的相关性。结果PET/CT超级迭代技术显示恶性组SUV_(max)、SUV_(mean)均高于良性组(P均<0.05)。以SUV_(max)、SUV_(mean)判断良恶性SPN的曲线下面积分别为0.738、0.847。随着肿瘤侵袭程度增加,恶性SPN的SUV_(max)、SUV_(mean)均呈升高趋势(P均<0.001)。Ki-67阳性SPN的SUV_(max)、SUV_(mean)均高于阴性者(P均<0.05)。恶性SPN的SUV_(max)、SUV_(mean)与其侵袭程度、Ki-67表达均呈正相关(r=0.340~0.452,P均<0.001)。结论PET/CT超级迭代技术所获SUV_(max)、SUV_(mean)与恶性SPN侵袭程度及Ki-67表达具有一定相关性,可用于判断良、恶性SPN。

Objective To observe the value of PET/CT super-iterative technique for diagnosing solitary pulmonary nodules(SPN)and evaluating degree of tumor invasion and Ki-67 expression.Methods A total of 53 patients with pathologically confirmed malignant SPN(malignant group)and 53 with benign SPN(benign group)who underwent PET/CT examination were enrolled.The maximum standard uptake value(SUV_(max))and the mean standard uptake value(SUV_(mean))were obtained with super-iterative technique.The value of PET/CT parameters for diagnosing benign and malignant SPN was analyzed using receiver operating characteristic curve.PET/CT parameters of malignant SPN were compared among different tumor invasion degrees and Ki-67 expression status.Spearman correlation analysis was used to evaluate the correlation of PET/CT parameters and malignant SPN invasion degree and Ki-67 expression.Results SUV_(max) and SUV_(mean) obtained with PET/CT super-iterative technique in malignant group were both higher than those in benign group(both P<0.05).The area under the curve of SUV_(max) and SUV_(mean) for diagnosing benign and malignant SPN was 0.738 and 0.847,respectively.With the increase of tumor invasion,SUV_(max) and SUV_(mean) of malignant SPN tended to increase(both P<0.001).SUV_(max) and SUV_(mean) of Ki-67 positive SPN were both higher than those of Ki-67 negative SPN(both P<0.05).SUV_(max) and SUV_(mean) of malignant SPN were positively correlated with its invasion degree and Ki-67 expression(r=0.340—0.452,all P<0.001).Conclusion Being correlated with the invasion degree and expression of Ki-67 of malignant SPN,SUV_(max) and SUV_(mean) obtained with PET/CT super-iterative techniques could be used to judge malignant or benign SPN.