成纤维细胞生长因子9的在骨骼系统中的功能

Biological characteristics of fibroblast growth factor 9 and its function in bone homeostasis

参与骨构建和重塑的细胞因子种类众多,其中成纤维细胞生长因子9属于成纤维细胞生长因子家族中的旁分泌亚家族,在骨组织中广泛分布,是骨构建和重塑中的重要负向调控因子。成纤维细胞生长因子9的异常突变会导致多种骨骼疾病的发生。本研究就成纤维细胞生长因子9在骨骼系统中的功能进行综述。

Many types of cytokines are involved in bone construction and remodeling,among which fibroblast growth factor 9,belonging to the parasecretory subfamily of the fibroblast growth factors family,is widely distributed in bone tissue and is an important negative regulator of bone construction and remodeling.Abnormal mutations in fibroblast growth factor 9 can lead to a variety of bone diseases.This article reviewed the function of fibroblast growth factor 9 in the skeletal system.