乳腺浸润性导管癌术后化疗并发营养不良脾胃虚弱证患者中应用养正合剂的临床观察

Clinical Observation of Yangzheng Mixture in Patients with Spleen and Stomach Weakness Complicated by Postoperative Chemotherapy for Breast Invasive Ductal Carcinoma

目的:研究养正合剂对乳腺浸润性导管癌术后化疗并发营养不良脾胃虚弱证患者的应用效果。方法:选取陕西中医药大学第二附属医院2019年12月至2021年1月收治的82例乳腺浸润性导管癌术后化疗并发营养不良脾胃虚弱证患者,随机分为观察组与对照组,各41例。予对照组患者常规治疗,观察组患者在对照组患者治疗基础上使用养正合剂,于治疗后比较两组患者中医证候疗效(中医症状评分),于治疗前后比较两组患者营养状况〔血清白蛋白(ALB)、载脂蛋白B100(ApoB100)、转铁蛋白(TRF)〕、免疫功能〔T辅助细胞(CD4^(+))、T杀伤细胞(CD8^(+))〕、于治疗结束后6个月比较两组患者肿瘤复发率。结果:治疗后,两组患者各中医症状评分、CD8^(+)比例均较前下降,且观察组患者明显低于对照组,差异有统计学意义(P<0.05)。两组患者血清ALB、ApoB100、TRF水平、CD4^(+)比例均较前显著上升,且观察组患者明显高于对照组,差异有统计学意义(P<0.05)。治疗结束后6个月,观察组患者肿瘤复发率为9.76%(4/41),低于对照组的14.63%(6/41),差异无统计学意义(P>0.05)。结论:养正合剂能有效改善乳腺浸润性导管癌术后化疗并发营养不良脾胃虚弱证患者营养状况,同时对于缓解患者各项症状,提高机体免疫功能有积极作用。

Objective To study the application of Yangzheng mixture in the treatment of patients with spleen and stomach weakness complicated by postoperative chemotherapy for breast invasive ductal carcinoma.Methods A total of 82 patients with postoperative chemotherapy for invasive ductal carcinoma of breast complicated with dystrophy of spleen and stomach weakness were selected from the Second Affiliated Hospital of Shaanxi University of Chinese Medicine from December 2019 to January 2021.These patients were randomly divided into an observation group and a control group,with 41 patients in each group.Patients in the control group received routine treatment,and patients in the observation group were treated with Yangzheng mixture on the basis of the treatment of patients in the control group.After treatment,the taditional Chinese medicine(TCM)syndrome efficacy(TCM symptom score)of patients in the two groups was compared.Nutritional status[serum albumin(ALB),apolipoprotein B100(ApoB100),transferrin(TRF)]and immune function[T helper cells(CD4^(+)),T killer cells(CD8^(+))]were compared between the two groups before and after treatment,and tumor recurrence rate was compared between the two groups 6 months after treatment.Results After treatment,the symptom score and CD8^(+)ratio in the two groups were decreased,and the indexes in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).The levels of serum ALB,ApoB100,TRF levels and CD4^(+)ratio in the two groups were significantly increased,and the levels in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).Six months after treatment,the recurrence rate of tumor in the observation group was 9.76%(4/41)lower than that in the control group 14.63%(6/41),with no statistical significance(P>0.05).Conclusion Yangzheng mixture can effectively improve the nutritional status of patients with the syndrome of spleen and stomach weakness complicated by postoperative chemotherapy for breast invasive ductal carcinoma,and has positive significance for relieving the symptoms of patients and improving the body's immune function.