健肺清浊汤对肺癌并胸腔积液患者胸腔循环热灌注化疗的辅助作用

Auxiliary Effect of Jianfei Qingzhuo Decoction on Hyperthermic Perfusion Chemotherapy of Thoracic Circulation in Patients with Lung Cancer and Pleural Effusion

目的:分析健肺清浊汤对肺癌并胸腔积液胸腔循环热灌注化疗患者血清指标的影响。方法:选取2018年1月至2020年12月在郑州市金水区总医院接受胸腔循环热灌注化疗的96例肺癌并胸腔积液患者,选取单纯化疗的48例患者纳入化疗组,另选取在化疗基础上应用健肺清浊汤治疗的48例患者纳入联合组。评估两组患者临床疗效,观察化疗前后两组患者临床指标的变化情况。结果:联合组患者总控制率高于化疗组,差异具有统计学意义(P<0.05);化疗后,联合组患者血清C反应蛋白(CRP)、糖类抗原(CA)199、癌胚抗原(CEA)均低于化疗组,差异具有统计学意义(P<0.05);化疗后,联合组患者CD3^(+)、CD4^(+)、CD8^(+)均高于化疗组,差异具有统计学意义(P<0.05);联合组患者化疗不良反应发生率为6.25%,低于化疗组的20.83%,差异具有统计学意义(P<0.05)。结论:健肺清浊汤能够辅助提高肺癌并胸腔积液胸腔循环热灌注化疗患者的临床疗效,改善血清指标。

Objective To analyze the effect of Jianfei Qingzhuo decoction on serum indexes of patients with lung cancer complicated with pleural effusion undergoing hyperthermic perfusion chemotherapy of thoracic circulation.Methods A total of 96 patients with lung cancer and pleural effusion were selected from January 2018 to December 2020 in Jinshui District General Hospital of Zhengzhou.48 patients with chemotherapy alone were selected to be included in the chemotherapy group,and 48 patients treated with Jianfei Qingzhuo decoction on the basis of chemotherapy were selected to be included in the combination group.The clinical effects of the two groups were evaluated,and the changes of clinical indexes of the two groups were observed before and after chemotherapy.Results The total control rate in the combination group was higher than that in the chemotherapy group,and the difference was statistically significant(P<0.05).After chemotherapy,the levels of serum C-reactive protein(CRP),carbohydrate antigen(CA)199 and carcinoembryonic antigen(CEA)in the combination group were lower than those in the chemotherapy group,and the differences were statistically significant(P<0.05).After chemotherapy,the levels of CD3^(+),CD4^(+)and CD8^(+)in the combination group were significantly higher than those in the chemotherapy group(P<0.05).The incidence of chemotherapy adverse reactions in the combination group was 6.25%,which was lower than 20.83%in the chemotherapy group,and the difference was statistically significant(P<0.05).Conclusion Jianfei Qingzhuo decoction can help improve the clinical effect and serum index of patients with lung cancer and pleural effusion undergoing hyperthermic perfusion chemotherapy of thoracic circulation.