阿卡波糖和二甲双胍治疗2型糖尿病的疗效分析

Analysis of the Efficacy of Acarbose and Metformin in the Treatment of Type 2 Diabetes Mellitus

目的:分析阿卡波糖和二甲双胍对2型糖尿病的治疗效果。方法:回顾性选取2018年7月至2022年6月期间三明市第一医院三钢分院收治的82例2型糖尿病患者作为研究对象。根据用药方法不同分为对照组和观察组,各41例。对照组采用阿卡波糖治疗,观察组采用二甲双胍治疗。治疗1个疗程后,比较两组患者治疗前后血糖指标、血脂指标,统计两组患者治疗期间不良反应。结果:治疗后,观察组患者空腹血糖、糖化血红蛋白水平、胰岛素抵抗指数均低于对照组,餐后2 h血糖高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组患者三酰甘油、总胆固醇、低密度脂蛋白水平均低于对照组,差异具有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿卡波糖与二甲双胍对于2型糖尿病的起效机制不同,治疗侧重方向也会有所不同,二甲双胍更适用于合并肥胖、血脂偏高、胰岛素抵抗的2型糖尿病患者治疗,而阿卡波糖更适用于餐后血糖较高的患者治疗。

Objective To analyze the therapeutic effect of acarbose and metformin on type 2 diabetes mellitus.Methods 82 patients with type 2 diabetes mellitus admitted to the Sanming First Hospital of Sangang Branch from July 2018 to June 2022 were retrospectively selected as the study subjects.According to different medication methods,they were divided into a control group and an observation group,with 41 cases in each group.The control group was treated with acarbose,and the observation group was treated with metformin.After one course of treatment,compare the blood glucose and lipid indicators of the two groups of patients before and after treatment,and calculate the adverse reactions of the two groups of patients during the treatment period.Results After treatment,the levels of fasting blood glucose,and glycated hemoglobin,and insulin resistance index of patients in the observation group were lower than those in the control group,and the levels of blood glucose 2 hours after meal was higher than that in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of triacylglycerol,total cholesterol,and low-density lipoprotein in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups of patients(P>0.05).Conclusion The mechanism of action of acarbose and metformin for type 2 diabetes mellitus is different,and the focus of treatment will also be different.Metformin is more suitable for type 2 diabetes mellitus patients with obesity,high blood lipids,and insulin resistance,while acarbose is more suitable for patients with high postprandial blood glucose.