期刊文献+

GPR、FIB–4及AAR对自身免疫性肝病患者早期肝硬化的诊断价值

下载PDF
导出
摘要 目的:探讨γ-谷酰胺转肽酶与血小板比值(GPR)、纤维化指数-4(FIB-4)、天门冬氨酸氨基转移酶与丙氨酸氨基转移酶比值(AAR)对自身免疫性肝病患者早期肝硬化的诊断价值。方法:选择2019年10月至2022年10月于邓州市中心医院就诊的60例自身免疫性肝炎患者,将其分为肝硬化组和非硬化组,分别为23例、37例。比较两组患者的GPR、FIB-4、AAR水平,采用受试者工作特征曲线(ROC)分析GPR、FIB-4、AAR对自身免疫性肝病患者早期肝硬化的诊断价值。结果:肝硬化组患者的GPR、FIB-4、AAR水平均比非肝硬化组患者高,差异均具有统计学意义(P<0.05);GPR、FIB-4、AAR对自身免疫性肝病患者早期肝硬化进行诊断的曲线下面积(AUC)值分别为0.977、0.929、0.765,而联合上述指标诊断的AUC值为0.994,显著高于各指标单独检测,差异具有统计学意义(P<0.05)。结论:GPR、FIB-4、AAR应用于自身免疫性肝病患者早期肝硬化的诊断中的临床价值较高,联合检测上述指标的价值高于单独检测。
机构地区 邓州市中心医院
出处 《深圳中西医结合杂志》 2023年第12期79-81,F0003,共4页 Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
  • 相关文献

参考文献14

二级参考文献193

  • 1陈敏灵,杨柳清,李亮,衡先培,吴韦贤,林伟.非酒精性脂肪性肝病患者肝脏脂肪含量与冠状动脉狭窄的相关性研究[J].血管与腔内血管外科杂志,2020,6(4):283-289. 被引量:4
  • 2Qixia Wang,Carlo Selmi,Xinmin Zhou,Dekai Qiu,Zenshan Li,Qi Miao,Xiaoyu Chen,Jianhong Wang,Edward L. Krawitt,M. Eric Gershwin,Ying Han,Xiong Ma.Epigenetic considerations and the clinical reevaluation of the overlap syndrome between primary biliary cirrhosis and autoimmune hepatitis[J].Journal of Autoimmunity.2012
  • 3Kirsten Muri Boberg,Roger W. Chapman,Gideon M. Hirschfield,Ansgar W. Lohse,Michael P. Manns,Erik Schrumpf.Overlap syndromes: The International Autoimmune Hepatitis Group (IAIHG) position statement on a controversial issue[J].Journal of Hepatology.2010(2)
  • 4Ansgar W. Lohse,Giorgina Mieli-Vergani.Autoimmune hepatitis[J].Journal of Hepatology.2010(1)
  • 5F. Alvarez,P.A. Berg,F.B. Bianchi,L. Bianchi,A.K. Burroughs,E.L. Cancado,R.W. Chapman,W.G.E. Cooksley,A.J. Czaja,V.J. Desmet,P.T. Donaldson,A.L.W.F. Eddleston,L. Fainboim,J. Heathcote,J.-C. Homberg,J.H. Hoofnagle,S. Kakumu,E.L. Krawitt,I.R. Mackay,R.N.M. MacSween,W.C. Maddrey,M.P. Manns,I.G. McFarlane,K.-H. Meyer zum Büschenfelde,G. Mieli-Vergani,Y. Nakanuma,M. Nishioka,E. Penner,G. Porta,B.C. Portmann,W.D. Reed,J. Rodes,S.W. Schalm,P.J. Scheuer,E. Schrumpf,T. Seki,G. Toda,T. Tsuji,N. Tygstrup,D. Vergani,M. Zeniya.International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis[J].Journal of Hepatology.1999(5)
  • 6Barbara Hoeroldt,Elaine McFarlane,Asha Dube,Pandurangan Basumani,Mohammed Karajeh,Michael J. Campbell,Dermot Gleeson.Long-term Outcomes of Patients With Autoimmune Hepatitis Managed at a Nontransplant Center[J].Gastroenterology.2011(7)
  • 7M. Sui,R. Wu,X. Hu,H. Zhang,J. Jiang,Y. Yang,J. Niu.Low prevalence of hepatitis B virus infection in patients with autoimmune diseases in a Chinese patient population[J]. J Viral Hepat . 2014 (12)
  • 8J. Chen,G. D. Eslick,M. Weltman.Systematic review with meta‐analysis: clinical manifestations and management of autoimmune hepatitis in the elderly[J]. Aliment Pharmacol Ther . 2014 (2)
  • 9Lisbet Gr?nb?k,Hendrik Vilstrup,Peter Jepsen.Autoimmune hepatitis in Denmark: Incidence, prevalence, prognosis, and causes of death. A nationwide registry-based cohort study[J]. Journal of Hepatology . 2013
  • 10Ersan Ozaslan,Cumali Efe,Alexandra Heurgué–Berlot,Taylan Kav,Chiara Masi,Tugrul Purnak,Luigi Muratori,Yücel Ustündag,Solange Bresson–Hadni,Gérard Thiéfin,Thomas D. Schiano,Staffan Wahlin,Paolo Muratori.Factors Associated With Response to Therapy and Outcome of Patients With Primary Biliary Cirrhosis With Features of Autoimmune Hepatitis[J]. Clinical Gastroenterology and Hepatology . 2014

共引文献424

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部