血常规指标对妊娠期高血压合并抑郁预测价值分析

Analysis of the Predictive Value of Blood Routine Indexes on Hypertensive Disorders of Pregnancy with Depression

目的:分析血常规指标对妊娠期高血压(HDP)合并抑郁的影响和预测价值,为临床预测HDP合并抑郁提供简单、廉价、有效的指标。方法:采用便利抽样法分析2021年5月至2023年1月在医院正常产检的HDP孕妇119例,根据抑郁自评量表(SDS)评分将所有孕妇分为抑郁组和非抑郁组。比较两组临床资料、血常规结果,分析血常规对HDP合并抑郁的影响和预测价值。结果:119例HDP孕妇合并抑郁发生率为26.05%,通过单因素、多因素Logistic分析显示:中性粒细胞/淋巴细胞(NLR)、血小板/淋巴细胞(PLR)、年龄均为HDP孕妇合并抑郁的独立影响因素,OR值分别为4.779、1.005、1.301;NLR、PLR、综合指标预测HDP合并抑郁的曲线下面积(AUC)分别为0.715、0.690、0.812,综合指标预测AUC均高于NLR和PLR,差异有统计学意义(P<0.05)。结论:血常规指标中NLR、PLR均为HDP合并抑郁的独立影响因素,且对其有一定预测价值,是可用于HDP是否合并抑郁的快速、廉价、有效的检测指标。

Objective:To analyze the influence and predictive value of blood routine indexes on depression combined with hypertensive disorders of pregnancy(HDP),and to provide simple,cheap and effective indexes for clinical prediction of depression combined with HDP.Methods:A convenient sampling method was used to analyze 119 cases of HDP pregnant women who had normal prenatal examination and delivery in our hospital from May 2021 to January 2023.All pregnant women were divided into depression group and non-depression group according to the score of the self-rating depression scale(SDS).The clinical data and blood routine results between the two groups were compared,and the influence and predictive value of blood routine on HDP combined with depression were analyzed.Results:The incidence of depression in 119 pregnant women with HDP was 26.05%.The univariate and multivariate analysis showed that neutrophils-to-lymphocytes ratio(NLR),platelets-to-lymphocytes ratio(PLR)and age were independent influencing factors of depression in pregnant women with HDP,and the OR values were 4.779,1.005 and 1.301,respectively.The area under the curve(AUC)predicted by NLR,PLR and comprehensive index were 0.715,0.690 and 0.812 respectively.The AUC predicted by the comprehensive index was higher than that of NLR and PLR,and the difference was statistically significant(P<0.05).Conclusions:NLR and PLR in blood routine indexes are independent influencing factors of HDP combined with depression,and have certain predictive value for its occurrence.NLR and PLR are fast,cheap and effective indicators that can be used to detect whether HDP is combined with depression.