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The discovery of the fat-regulating phosphatidic acid phosphatase gene 被引量:1

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摘要 Phosphatidic acid phosphatase is a fat-regulating enzyme that plays a major role in controlling the balance of phosphatidic acid(substrate)and diacylglycerol(product),which are lipid precursors used for the synthesis of membrane phospholipids and triacylglycerol.Phosphatidic acid is also a signaling molecule that triggers phospholipid synthesis gene expression,membrane expansion,secretion,and endocytosis.While this important enzyme has been known for several decades,its gene was only identified recently from yeast.This discovery showed the importance of phosphatidic acid phosphatase in lipid metabolism in yeast as well as in higher eukaryotes including humans.
出处 《Frontiers in Biology》 CSCD 2011年第3期172-176,共5页 生物学前沿(英文版)
基金 supported in part by National Institutes of Health Grant GM-28140.
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