湖北地区4819例HPV感染亚型分布及差异分析

Distribution and difference analysis of HPV subtypes in 4 819 cases in Hubei province

目的 探讨湖北地区4 819例HPV感染亚型分布及差异分析。方法 选取2022年2-12月在武汉大学人民医院就诊并进行脱落细胞标本HPV 27种基因分型检测的患者共4 819例患者,其中男性277例,女性4 542例,男性年龄18~86岁,女性年龄16~85岁。采用流式荧光杂交分型检测方法对其进行27种HPV亚型检测。结果 男性患者HPV6、11、42、52、53、58、61、68感染率与女性患者比较,差异有统计学意义(P<0.05),其中HPV6、11感染率高于女性患者(P<0.05),均为低危型HPV亚型;而HPV42、52、53、58、61、68感染率低于女性患者(P<0.05),其中HPV52、53、58、68为高危型HPV亚型,42、61为低危型HPV亚型。男性单纯低危型HPV感染率、多重风险混合型HPV感染率明显高于女性,而单重单纯高危型HPV感染率、总单纯高危型HPV感染率明显低于女性,差异有统计学意义(P<0.05)。单纯高危型HPV感染和多重风险混合型HPV感染以中年人感染居多。结论 湖北地区男性与女性HPV感染具有差异,男性HPV感染倾向于低危型,而女性HPV感染倾向于高危型,且均集中于中年感染。

Objective To investigate the distribution and difference analysis of HPV subtypes in 4819 cases in Hubei province.Methods A total of 4819 patients,including 277 males and 4542 females,aged 18 to 86 and 16 to 85 years,were selected from the People′s Hospital of Wuhan University from February to December in 2022 and tested for HPV27 subtypes of cell samples.27 subtypes of HPV were detected by flow fluorescence hybridization.Results The infection rate of HPV6,11,42,52,53,58,61 and 68 in male patients was significantly higher than that in female patients(P<0.05),and the infection rate of HPV6 and 11 was higher than that in female patients(P<0.05),and all were low-risk HPV subtypes.The infection rate of HPV42,52,53,58,61,68 was lower than that of female patients(P<0.05),among which HPV52,53,58,68 were high-risk HPV subtypes,42,61 were low-risk HPV subtypes.The infection rate of simple low-risk HPV and multi-risk mixed HPV in males was significantly higher than that in females,while the infection rate of single high-risk HPV and total high-risk HPV were significantly lower than that in females,with statistical significance(P<0.05).Simple high-risk HPV infection and multi-risk mixed HPV infection are mostly in middle-aged people.Conclusion There are differences in HPV infection between male and female in Hubei province.Male HPV infection tends to be low-risk type,while female HPV infection tends to be high-risk type,and all of them are concentrated in middle age.