运动与AMPK/mTOR轴介导细胞自噬改善肌肉减少性肥胖的研究进展

Advances in Exercise and AMPK/mTOR Axis-mediated Cellular Autophagy to Improve Sarcopenic Obesity

肌肉减少性肥胖(SO)是一种与衰老相关的肥胖型疾病,主要病症表现为骨骼肌质量、力量或功能下降,以及脂肪含量的上升.SO中的蛋白质与脂肪的合成分解失衡,体内细胞自噬水平下降或发生障碍是重要因素之一.运动作为重要的代谢调节手段,可通过腺苷酸活化蛋白激酶(AMPK)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路调控体内自噬水平,促进细胞自噬,起到重塑骨骼肌与调控内环境稳态,维持骨骼肌健康和增加脂肪消耗的作用,是改善和逆转SO的关键.

Sarcopenic obesity(SO)is an obesity-related disease associated with aging,characterized by decreased skeletal muscle mass,strength or function,and increased fat content.The imbalance between synthesis and degradation of protein and fat and the decrease or disorder of autophagy in the body are important factors in SO.Exercise is an important metabolic regulator of autophagy in the body through the adenosine monophosphate-activated protein kinase(AMPK)/mammalian target of rapamycin(mTOR)signaling pathway.Promoting autophagy plays a role in remodeling skeletal muscle,regulating homeostasis,maintaining skeletal muscle health and increasing fat consumption and is key to countering and reversing SO.