炎症细胞因子与胚胎停育的关系

The Relationship between Inflammatory Cytokines and Embryo Arrest

胚胎停育是指因受精卵缺陷或母体存在不利于妊娠因素而导致妊娠早期胚胎死亡而停止继续发育的现象,是一种常见的早期病理性妊娠。其发病率逐年增加,已成为最常见的妊娠并发症,最终可导致自然流产、稽留流产的发生。胚胎停育发生与许多因素有关,其中约半数与免疫因素有关。细胞因子是一类能调节免疫反应的生物活性分子,其中与炎症有关的称为炎症细胞因子。子宫蜕膜、滋养层细胞可以分泌多种炎症细胞因子。近年研究表明,在胚胎发育过程中多种炎症细胞因子之间相互协同、依赖又相互拮抗构成细胞因子网络,参与母胎界面免疫应答,使其导致胚胎停育的确切机制及信号通路错综复杂。综述炎症细胞因子与胚胎停育的关系及相关机制,以期为胚胎停育的预防和开发靶向治疗药物奠定理论基础。

Embryo arrest is a common early pathological pregnancy in which is caused by defects of fertilized eggs or adverse pregnancy factors of the mother,resulting in the embryo to stop developing during pregnancy.The incidence of embryo arrest has increased year by year,becoming the most common complication of pregnancy.It may eventually lead to spontaneous abortion and missed abortion.Many factors are related to the occurrence of embryo arrest and about half of them are related to immune factors.Cytokines are a class of biologically active molecules that modulate immune response,among which inflammatory cytokines are related to inflammation.Uterine decidua and trophoblast cells can secrete a variety of inflammatory cytokines.Recent studies have shown that in the process of embryonic development,different cytokines cooperate,depend on and antagonize each other to form a cytokine network and participate in the maternal fetal interface immune response.But the exact mechanism of inducing embryo arrest is still unclear.This review focused on the relationship between inflammatory cytokines and embryo arrest and the related mechanism,in order to laying a theoretical foundation for the prevention of embryonic abortion and the development of targeted therapeutic agents.