网膜素1水平对于冠状动脉粥样硬化性心脏病疾病程度的相关性研究

Study on the correlation between omentin-1 level and degree of coronary heart disease

目的探讨血浆网膜素1(Omentin-1)对于冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)疾病程度的相关性。方法选取住院期间行冠状动脉造影并诊断为CHD的患者114例,其中不稳定型心绞痛(unstable angina,UA)43例、稳定型心绞痛(stable angina,SA)27例、急性心肌梗死(acute myocardial infarction,AMI)44例,另选取同一时间段内行冠状动脉造影显示无狭窄患者29例为对照组。比较患者的一般资料及实验室检查,采用酶联免疫吸附法检测血浆Omentin-1水平。采用冠状动脉病变评分(Gensini)评估冠状动脉病变狭窄程度。Logistic回归分析冠状动脉病变狭窄程度的影响因素。Pearson相关分析Gensini评分与血浆Omentin-1水平之间存在的相关性。结果与对照组比较,UA、AMI组男性比例、年龄、吸烟比例较高,高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)较低,SA、UA、AMI组高血压病比例较高,AMI组糖尿病比例、低密度脂蛋白胆固醇(low density lipoprotein cholesterin,LDL-C)较高,左心室射血分数(left ventricular ejection fraction,LVEF)、Omentin-1较低,差异有统计学意义(P<0.05)。与SA组比较,UA、AMI组男性比例多,吸烟史比例较高,AMI组LDL-C较高、LVEF、Omentin-1较低,差异有统计学意义(P<0.05)。与UA组比较,AMI组男性比例、LVEF、Omentin-1较低,糖尿病病史比例、LDL-C较高,差异有统计学意义(P<0.05)。与轻度狭窄组比较,重度狭窄组糖尿病比例、LDL-C较高,LVEF较低,中度狭窄和重度狭窄组Omentin-1较低,差异有统计学意义(P<0.05)。与中度狭窄组比较,重度狭窄患者LDL-C较高,Omentin-1较低,差异有统计学意义(P<0.05)。Logistic回归分析结果显示,性别、吸烟史、糖尿病史、LDL-C、LVEF、血浆Omentin-1是CHD冠状动脉狭窄程度的危险因素(P<0.05)。Pearson相关分析显示,CHD组血浆Omentin-1水平与Gensini评分呈负相关关系(r=-0.766,P<0.05)。结论血浆Omentin-1水平与冠状动脉严重程度存在负相关关系,高水平的血浆Omentin-1在冠状动脉疾病发病机制中起保护作用。因此血浆Omentin-1可以作为预测CHD发生发展、评估冠状动脉病变严重程度,成为CHD进展的潜在生物标志物。

Objective To investigate the correlation of plasma omentin-1 with the degree of coronary heart disease(CHD).Methods A total of 114 patients who underwent coronary angiography during hospitalization and were diagnosed with CHD were enrolled,including 43 cases of unstable angina(UA),27 cases of stable angina(SA),and 44 cases of acute myocardial infarction(AMI).Another 29 patients without stenosis by coronary angiography during the same time period were selected as the control group.The general data and laboratory tests of patients were compared,and plasma omentin-1 levels were measured by enzyme-linked immunosorbent assay(ELISA).The coronary artery disease score(Gensini)was used to assess the degree of stenosis of coronary artery disease.Logistic regression was used to analyze the factors influencing the degree of stenosis of coronary artery lesions.Pearson correlation analysis was used to analyze the correlation between Gensini scores and plasma Omentin-1 levels.Results Compared with the control group,the proportion of males,age and smoking in the UA and AMI groups were higher,while HDL-C was lower;The proportion of hypertension in the SA,UA and AMI groups was higher,the proportion of diabetes and LDL-C in the AMI group was higher,while the LVEF and omentin-1 were lower,suggesting significant difference(P<0.05).Compared with the SA group,the proportion of males and smoking history in the UA and AMI groups was higher,and the LDL-C was higher,while LVEF and omentin-1 were lower in the AMI group,suggesting significant difference(P<0.05).Compared with the UA group,the proportion of males,LVEF,and omentin-1 in the AMI group was lower,while the proportion of diabetes history and LDL-C were higher in the AMI group,suggesting significant difference(P<0.05).Compared with the mild stenosis group,the proportion of diabetes and LDL-C were higher,while LVEF was lower in severe stenosis group,and omentin-1 was lower in the moderate and severe stenosis groups,with significant difference(P<0.05).Compared with the moderate stenosis group,patients with severe stenosis had higher LDL-C and lower omentin-1,suggesting significant difference(P<0.05).The results of logistic regression analysis showed that sex,smoking history,diabetes history,LDL-C,LVEF,and plasma omentin-1 were risk factors for coronary artery stenosis in patients with CHD(P<0.05).Pearson correlation analysis showed that plasma omentin-1 levels in the CHD group were negatively correlated with Gensini score(r=-0.766,P<0.05).Conclusion There is a negative correlation between plasma omentin-1 levels and degree of coronary artery disease,and high levels of plasma omentin-1 play a protective role in the pathogenesis of coronary artery disease.Therefore,plasma omentin-1 can be used for predicting the occurrence and progression of CHD,assessing the severity of coronary artery lesions,and becoming a potential biomarker for CHD progression.