血清超敏C反应蛋白与前白蛋白比值对慢性心力衰竭心室重构的诊断价值研究

Diagnostic Value of Serum High-Sensitivity C-Reactive Protein to Prealbumin Ratio for Ventricular Remodeling in Chronic Heart Failure

目的:探讨血清超敏C反应蛋白(hs-CRP)与前白蛋白(PAB)比值对慢性心力衰竭心室重构的诊断价值。方法:选取2020年4月—2022年4月锦州医科大学附属第一医院心血管内科收治的慢性心力衰竭患者85例作为观察组,另选取同期进行体检的健康者80例作为对照组。比较两组hs-CRP/PAB、心脏超声心室重构相关超声指标,并采用Pearson分析hs-CRP/PAB与心室重构超声指标的相关性,采用Logistic回归分析hs-CRP/PAB可否作为慢性心力衰竭心室重构的独立危险因素。结果:观察组hs-CRP表达水平、ln(hs-CRP/PAB)高于对照组,差异有统计学意义(P<0.001)。观察组PAB低于对照组,差异有统计学意义(P<0.001)。观察组左心室射血分数(LVEF)指标低于对照组,左心房内径(LAD)、左心室舒张末期内径(LVEDD)均高于对照组,差异有统计学意义(P<0.001)。hs-CRP/PAB与LVEF呈负相关,与LAD、LVEDD呈正相关,差异有统计学意义(P<0.001)。Logistic回归分析显示,hs-CRP/PAB是慢性心力衰竭心室重构的独立危险因素(P<0.001)。结论:hs-CRP/PAB在慢性心力衰竭心室重构中具有一定诊断价值,hs-CRP/PAB水平与慢性心力衰竭心室重构具有相关性,hs-CRP/PAB增加,容易引起慢性心力衰竭心室重构。

Objective:To explore the diagnostic value of serum high-sensitivity C-reactive protein(hs-CRP) to prealbumin ratio(PAB) ratio for ventricular remodeling in chronic heart failure.Methods:From April 2020 to April 2022,85 chronic heart failure patients admitted to Department of Cardiovascular Medicine in the First Affiliated Hospital of Jinzhou Medical University were selected as observation group,and another 80 healthy people for physical examination during the same period were selected as control group.The hs-CRP/PAB and cardiac ultrasound indexes related to ventricular remodeling were compared between the two groups.Pearson analysis was performed for the correlation between hs-CRP/PAB and ventricular remodeling ultrasound indexes.Logistic regression analysis was performed to analyze whether hs-CRP/PAB could be used as an independent risk factor for ventricular remodeling in chronic heart failure.Results:The expression level of hs-CRP and ln(hs-CRP/PAB) in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.001).The PAB in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.001).The left ventricular ejection fraction(LVEF) index in the observation group was lower than that in the control group,and the left atrial diameter(LAD) and left ventricular end-diastolic diameter(LVEDD) in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.001).The hs-CRP/PAB was negatively correlated with LVEF,and positively correlated with LAD and LVEDD,and the difference was statistically significant(P<0.001).Logistic regression analysis showed that hs-CRP/PAB was an independent risk factor for ventricular remodeling in chronic heart failure(P<0.001).Conclusion:The hs-CRP/PAB has certain diagnostic value for ventricular remodeling in chronic heart failure,and the level of hsCRP/PAB is correlated with ventricular remodeling in chronic heart failure,and the increase of hs-CRP/PAB is easy to cause ventricular remodeling in chronic heart failure.