不同剂量孕激素治疗无排卵型月经失调的疗效观察

Observation of curative effect of different doses of progesterone in the treatment of anovulatory menstrual disorders

目的探讨不同剂量孕激素治疗无排卵型月经失调的效果。方法选择158例无排卵型月经失调患者为研究对象,按治疗剂量不同分为对照组和研究组,每组79例。对照组给予孕激素300mg/d,研究组给予孕激素200mg/d,观察两组患者阴道流血、子宫内膜厚度、激素水平及不良反应发生率。结果用药前,两组子宫内膜厚度及激素水平比较,差异无统计学意义(P>0.05);用药后,研究组子宫内膜厚度低于对照组,出血量少于对照组,出血持续时间短于对照组,各项激素水平均低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论无排卵型月经失调患者实施小剂量激素治疗能够改善子宫内膜厚度,并减少患者出血量,缩短出血时间,改善激素水平,同时治疗期间安全性较高,值得临床推广与应用。

Objective To investigate the therapeutic effect of different doses of progesterone in the treatment of anovulatory menstrual disorders.Methods A total of 158 patients with anovulatory menstrual disorder were selected as the study objects,and were divided into control group and study group according to different therapeutic dose,79 cases in each group.The control group was given progesterone 300 mg/d,and the study group was given progesterone 200 mg/d.Vaginal bleeding,endometrial thickness,hormone levels and the incidence of adverse reactions were observed in both groups.Results Before medication,there were no significant differences in endometrial thickness and hormone levels between the two groups(P>0.05).After treatment,the endometrial thickness,bleeding amount,bleeding duration and hormone levels in the study group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Small-dose hormone therapy for patients with anovulatory menstrual disorders can improve endometrial thickness,reduce blood loss,shorten bleeding time,and improve hormone levels.At the same time,it is safe during treatment and worthy of clinical promotion and application.