痰热清注射液治疗脓毒症的疗效及对炎性反应的影响

Clinical effect of Tanreqing injection for sepsis and the impact on inflammatory reaction

目的观察痰热清注射液治疗脓毒症的疗效及对炎性反应的影响。方法选取2017年8月—2018年7月贵阳市第一人民医院收治的140例脓毒症患者作为研究对象,根据治疗方法分为对照组与观察组,各70例。对照组患者采用常规西药治疗,观察组患者在对照组基础上加用痰热清注射液治疗,2组治疗时间均为7 d。比较2组临床疗效,治疗前及治疗7 d后急性生理学及慢性健康状况评分系统Ⅱ(APACHEⅡ)评分、血清炎性因子[降钙素原(PCT)、C反应蛋白(CRP)、白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)],ICU入住时间、总住院时间及并发症发生情况。结果观察组总有效率较对照组高(97.14%vs.77.14%,χ^(2)=12.495,P<0.001)。治疗7 d后,2组APACHEⅡ评分较治疗前降低,且观察组低于对照组(P<0.01);2组血清PCT、CRP、IL-6、IL-8、TNF-α水平较治疗前均降低,且观察组低于对照组(P<0.01)。观察组总住院时间短于对照组(P<0.01),但2组ICU入住时间比较,差异无统计学意义(P>0.05)。观察组并发症总发生率与对照组比较,差异无统计学意义(8.57%vs.2.86%,χ^(2)=1.193,P=0.275)。结论痰热清注射液用于脓毒症患者治疗中可获得较好的效果,可有效减轻机体炎性反应,缩短住院时间,改善患者的身体状况,且预后良好。

Objective To observe the clinical effect of Tanreqing injection for sepsis and the impact on inflammatory reaction.Methods A total of 140 cases of patients with sepsis were selected from August 2017 to July 2018 in the First People′s Hospital of Guiyang,and divided into the control group and the observation group by treatment methods,70 cases in each group.The control group was given conventional western medicine treatment,and the observation group was given Tanreqing injection based on the control group,both groups were treated for 7 days.Clinical efficacy,APACHEⅡscore,serum inflammatory factors(PCT,CRP,IL-6,IL-8,TNF-α)before and after 7 days of treatment,ICU admission time and total hospitalization time,and incidence of complications were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(97.14%vs.77.14%,χ^(2)=12.495,P<0.001).After 7 days of treatment,APACHEⅡscore of the two groups was lower than that before treatment,and that of the observation group was lower than control group(P<0.01);Serum levels of PCT,CRP,IL-6,IL-8,TNF-αof the two groups were lower than those before treatment,and those of the observation group were lower than control group(P<0.01).Compared with that of the control group,total hospitalization time of the observation group was shorter(P<0.01),but there was no significant difference of ICU admission time between the two groups(P>0.05).There was no significant difference in the incidence of complications between the observation group and the control group(8.57%vs.2.86%,χ^(2)=1.193,P=0.275).Conclusion For patients with sepsis,Tanreqing injection has better clinical effect,it can effectively reduce the inflammatory reaction of the body,shorten the hospitalization time,improve the physical condition of patients,and has a good prognosis.