抑郁症患者血清维生素B_(12)、25(OH)D水平表达的临床意义及对预后的影响

Clinical significance of expression levels of serum vitamin B_(12)and 25(OH)D in patients with depression and its influence on prognosis

目的观察抑郁症患者血清维生素B_(12)和25羟维生素D[25(OH)D]表达情况,并分析二者对抑郁症预后的影响。方法纳入120例抑郁症患者,均行为期1年的随访,以随访期间病情进展为难治性抑郁症作为评估预后的标准,记录随访期间难治性抑郁症发生情况并分组(预后良好组和预后不良组),设计一般资料调查表,记录基线资料及实验室指标,重点分析首次就诊当天血清维生素B_(12)、25(OH)D水平对抑郁症患者预后的影响。结果随访1年时,难治性抑郁症发生率为26.67%;预后不良组血清维生素B_(12)、25(OH)D水平均低于预后良好组(P<0.05);经多项Logistic回归分析结果显示,抑郁症患者就诊当天的血清维生素B_(12)和25(OH)D水平高是抑郁症患者预后不良的保护因素(P<0.05)。结论血清维生素B_(12)、25(OH)D水平能够对抑郁症患者的预后情况产生影响。

Objective To explore the expression levels of serum vitamin B_(12)and 25 hydroxyvitamin D[25(OH)D]in patients with depression,and to analyze their influences on the prognosis of depression.Methods 120 patients with depression were prospectively included and followed-up for one year.The progress of the disease during the follow-up period was regarded as refractory depression as the standard for assessing prognosis.The occurrence of refractory depression during the follow-up period was recorded and treated as a standard to divide the subjects into good prognosis group and poor prognosis group.A general information questionnaire was designed to record baseline data and laboratory indicators,and the effects of serum vitamin B_(12)and 25(OH)D levels on the first visit on the prognosis of patients with depression were mainly analyzed.Results During one year of follow-up,32 patients developed into refractory depression among all the 120 patients,with an incidence of 26.67%.The serum levels of vitamin B_(12)and 25(OH)D in poor prognosis group were lower than those in good prognosis group(P<0.05).Multifactor logistic regression analysis showed that high serum levels of vitamin B_(12)and 25(OH)D on the day of first visit were protective factors for poor prognosis in patients with depression(P<0.05).Conclusion Serum levels of vitamin B_(12)and 25(OH)D can affect the prognosis in patients with depression.