卡培他滨联合多西紫杉醇治疗胃癌患者的疗效及对免疫功能的影响研究

Study on efficacy of capecitabine combined with docetaxel in the treatment of patients with gastric cancer and its influence on immune function

目的 探究卡培他滨联合多西紫杉醇治疗胃癌患者的疗效及对免疫功能的影响。方法 84例胃癌患者作为研究对象,根据随机数字表法分为对照组和研究组,每组42例。对照组患者采用氟尿嘧啶联合多西紫杉醇治疗,研究组患者采用卡培他滨联合多西紫杉醇治疗。对比两组患者临床疗效,用药前后免疫功能[免疫球蛋白M(IgM)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)],不良反应发生情况。结果 研究组用药后的总有效率64.29%高于对照组的42.86%,差异具有统计学意义(P<0.05)。用药前,两组的IgM、IgG、IgA水平对比差异无统计学意义(P>0.05);用药后,两组患者的IgM、IgG、IgA水平均低于用药前,差异具有统计学意义(P<0.05);两组用药后IgM、IgG、IgA水平对比差异无统计学意义(P>0.05)。研究组不良反应发生率为11.90%,显著低于对照组的30.95%,差异具有统计学意义(P<0.05)。结论 卡培他滨联合多西紫杉醇治疗胃癌患者的效果好,可保护免疫功能,且减少不良反应。

Objective To investigate the efficacy of capecitabine combined with docetaxel in the treatment of patients with gastric cancer and its influence on immune function.Methods A total of 84 patients with gastric cancer were divided into control group and study group according to the random numerical table,with 42 cases in each group.The control group was treated with fluorouracil and docetaxel,and the study group was treated with capecitabine and docetaxel.The clinical efficacy,immune function[immunoglobulin M(IgM),immunoglobulin G(IgG),immunoglobulin A(IgA)],and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of 64.29%in the study group was higher than that of 42.86%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in levels of IgM,IgG and IgA between the two groups(P>0.05).After treatment,the levels of IgM,IgG and IgA in both groups were lower than those before treatment in this group,and the differences were statistically significant(P<0.05).After treatment,there was no statistically significant difference in levels of IgM,IgG and IgA between the two groups(P>0.05).The incidence of adverse reactions was 11.90%in the study group,which was significantly lower than that of 30.95%in the control group,and the difference was statistically significant(P<0.05).Conclusion Capecitabine combined with docetaxel has a significant effect in the treatment of gastric cancer patients,which can protect their immune function and reduce adverse reactions.