摘要
目的:探究颈动脉超声参数结合血浆小而密低密度脂蛋白(sd-LDL)评估糖尿病患者动脉粥样硬化性心血管疾病(ASCVD)的临床价值。方法:回顾性分析医院于2022年7月至2022年12月收治的104例糖尿病患者临床资料,将单纯性糖尿病患者纳入对照组(n=51),合并有ASCVD的患者纳入观察组(n=53),比较两组颈动脉超声参数以及sd-LDL,采用Logistic回归分析糖尿病患者ASCVD的影响因素并探究颈动脉超声参数与sd-LDL对评估糖尿病患者ASCVD的临床价值。结果:观察组颈动脉超声参数:颈动脉内中膜厚度(IMT)、斑块积分均高于对照组,sd-LDL水平高于对照组(P<0.05);两组吸烟人数比较差异具有统计学意义(P<0.05);其余临床资料比较差异无统计学意义(P>0.05);Logistic多因素回归分析,结果显示:IMT、斑块积分、sd-LDL水平为糖尿病患者合并ASCVD的影响因素(P<0.05)。结论:颈动脉超声参数以及sd-LDL在评估糖尿病患者ASCVD中具有较高临床价值,临床可联合颈动脉超声参数中的IMT、斑块积分及sd-LDL水平对ASCVD进行初步评估,为临床诊断与治疗ASCVD提供依据。
Objective:To investigate the clinical value of carotid artery ultrasound parameters combined with plasma small and dense low-density lipoprotein(sd-LDL)in evaluating atherosclerotic cardiovascular disease(ASCVD)in diabetic patients.Methods:The clinical data of 104 diabetic patients admitted to the hospital from July to December 2022 were analyzed retrospectively.Patients with simple diabetes were defined as the control group(n=51)and those with ASCVD were defined as the observation group(n=53).Carotid artery ultrasound parameters and sd-LDL were compared between groups.Logistic regression analysis was performed to screen the influencing factors of ASCVD in diabetic patients.The clinical value of carotid artery ultrasound parameters and sd-LDL in evaluating ASCVD in diabetic patients was discussed.Results:Carotid artery ultrasound parameters(carotid intima-media thickness(IMT)and plaque score)and sd-LDL level in the observation group were larger/higher than the control group(P<0.05).The numbers of smokers in the two groups were close(P<0.05).Logistic regression analysis found that IMT,plaque score and sd-LDL level were influencing factors of ASCVD in diabetic patients(P<0.05).Conclusion:Carotid artery ultrasound parameters and sd-LDL are much helpful for evaluating ASCVD in diabetic patients.Clinically,combination of IMT and plaque score and sd-LDL level can be adopted to provide a basis for clinical diagnosis and treatment of ASCVD.
作者
孙晓婷
郭丹
范瑞龙
闫炜
SUN Xiaoting(Linfen Central Hospital,Shanxi Linfen 041000,China)
出处
《河北医学》
CAS
2023年第8期1340-1344,共5页
Hebei Medicine
基金
山西省卫生健康委科研课题,(编号:2020160)。
关键词
糖尿病
动脉粥样硬化性心血管疾病
颈动脉超声参数
血浆小而密低密度脂蛋白
Diabetes
Atherosclerotic cardiovascular disease
Carotid artery ultrasound parameter
Plasma small and dense low-density lipoprotein