腰痛宁胶囊联合整脊手法对改善椎间盘源性腰痛患者疼痛及腰部功能障碍的临床研究

Clinical Study on the Combination of Yaotongning Capsule and Spinal Micro-Adjustment Manipulation on Improving Pain and Lumbar Dysfunction in Patients with Discogenic Low Back Pain

目的:观察脊柱微调整脊手法联合药物治疗寒湿痹阻型椎间盘源性腰痛的临床有效性和安全性。方法:选取符合寒湿痹阻型椎间盘源性腰痛诊断标准的患者70例,随机分为治疗组和对照组各35例;治疗组应用脊柱微调整脊手法联合中药制剂腰痛宁胶囊进行治疗,对照组采用脊柱微调整脊手法联合双氯芬酸钠缓释片进行治疗,比较两组患者治疗前及治疗1周、3周、6周的疼痛视觉模拟评分(VAS)、Oswestry功能障碍指数(ODI)、日本骨科学会评分(JOA)及安全性指标,并进行评价。结果:二组患者治疗1周、3周、6周后,VAS评分、ODI评分、JOA评分均比治疗前有所改善(P<0.05),其中3周前治疗组疗效弱于对照组,而6周后治疗组疗效与对照组相当,腰部功能改善评估满意度为97%,腰部功能改善率为86%,总优良率为97%,治疗组不良反应发生率比对照组低。结论:脊柱微调整脊手法联合中成药腰痛宁胶囊能够明显改善椎间盘源性腰痛寒湿痹阻证的临床症状,疗效确切,且治疗6周效果更为明显。

Objective:To study the clinical efficacy and safety of spinal micro-adjustment manipulation combined with drug Yaotongning capsule in treating discogenic low back pain(DLBP)with cold-dampness obstruction syndrome.Methods:Seventy patients with DLBP were randomly divided into a treatment group and control group,35 cases in each group.Yaotongning capsules and spinal micro-adjustment manipulation were used to treat the patients in the treatment group,whereas Diclofenac sodium sustained-release tablets and spinal micro-adjustment manipulation were used to treat the patients in the control group.The Oswestry disability index(ODI),Japanese orthopaedic association scores(JOA),visual analogue scale(VAS)and safety indicators of the two groups were compared and evaluated before treatment and 1,3 and 6 weeks after treatment.The satisfaction rate with the evaluation of lumbar function improvement is 97%,the improvement rate of lumbar function is 86%,and the overall excellent and good rate is 97%..Results:After 1 week,3 weeks and 6 weeks of treatment,patients in the two groups had improvements in their VAS,ODI,and JOA scores when compared to their pre-treatment scores(P<0.05).The treatment group's effectiveness was inferior to the control group's before three post-operative weeks,but it was comparable to that of the control group by six weeks.However,the treatment group experienced fewer adverse responses than the control group did at that time.Conclusion:Spinal micro-adjustment manipulation combined with Chinese patent medicine Yaotongning capsule could significantly improve the clinical symptom of DLBP with cold-dampness obstruction syndrome,and the effect was more obvious after 6 weeks of treatment.