小儿肺热咳喘颗粒联合阿莫西林克拉维酸钾治疗小儿支原体肺炎的临床研究

Clinical study on Xiao’er Feire Kechuan Granules combined with amoxicillin and clavulanate potassium in treatment of mycoplasma pneumonia in children

目的 探讨小儿肺热咳喘颗粒联合阿莫西林克拉维酸钾颗粒治疗小儿支原体肺炎的临床效果。方法 选取2020年8月—2022年8月无锡市第九人民医院就诊的92例小儿支原体肺炎患儿,采用奇偶数法将患儿分为对照组和治疗组,每组各46例。对照组患儿口服阿莫西林克拉维酸钾颗粒,25 mg/kg,1次/12 h。治疗组患儿在对照组基础上开水冲服小儿肺热咳喘颗粒,3 g/次,3周岁以下患儿3次/d,3周岁以上患儿4次/d。两组患儿均连续治疗10 d。观察两组的临床疗效,比较两组的临床症状消失时间、血清炎症因子。结果 治疗后,治疗组的总有效率95.65%明显高于对照组80.43%,差异有统计学意义(P<0.05)。治疗后,治疗组发热、咳嗽、肺部干湿啰音消失时间均明显短于对照组,差异具有统计学意义(P<0.05)。治疗后,两组血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平均明显下降(P<0.05),且治疗组血清IL-6、TNF-α、CRP水平明显低于对照组,差异有统计学意义(P<0.05)。结论 小儿肺热咳喘颗粒联合阿莫西林克拉维酸钾治疗小儿支原体肺炎可明显提高疗效,加快患儿临床症状消失,有效减轻体内炎症反应,具有良好的安全性。

Objective To explore clinical effect of Xiao’er Feire Kechuan Granules combined with Amoxicillin and Clavulanate Potassium Granules in treatment of mycoplasma pneumonia in children.Methods Children(92 cases)with mycoplasma pneumonia in Wuxi Ninth People’s Hospital from August 2020 to August 2022 were divided into control and treatment groups according to the odd even number method,and each group had 46 cases.Children in the control group were po administered with Amoxicillin and Clavulanate Potassium Granules,25 mg/kg,once every 12 h.Children in the treatment group were po administered with Xiao’er Feire Kechuan Granules on the basis of the control group,3 g/time,under 3 years old,three times daily,over 3 years old,three times daily.Children in two groups were treated for 10 d.After treatment,the clinical efficacies were evaluated,and the clinical symptom disappearance time,and serum inflammatory factors in two groups were compared.Results After treatment,the total effective rate(95.65%)of the treatment group was significantly higher than 80.43%of the control group,with a statistically significant difference(P<0.05).After treatment,the disappearance time of fever,cough,and lung dry and wet rales in the treatment group was significantly shorter than that in the control group,with a statistically significant difference(P<0.05).After treatment,the serum levels of IL-6,TNF-α,and CRP in two groups were significantly decreased(P<0.05),and the serum levels of IL-6,TNF-α,and CRP in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Xiao’er Feire Kechuan Granules combined with Amoxicillin and Clavulanate Potassium Granules in treatment of mycoplasma pneumonia in children can significantly improve the efficacy,accelerate the disappearance of clinical symptoms in children,effectively reduce inflammation in vivo,with good safety.