血清C肽与糖化血红蛋白诊断糖尿病的价值分析

Analysis of the effect and detection rate of serum C peptide and glycosylated hemoglobin test in the diagnosis ofdiabetes mellitus

目的 分析血清C肽(CP)、糖化血红蛋白(HbA1c)在糖尿病(DM)诊断中的临床价值。方法 本次研究对象选取兴山县人民医院2019年11月—2021年11月住院的50例DM患者作为观察组,以同期于门诊体检的50例健康人员作为对照组,检测、对比2组血清CP、HbA1c水平以及阳性检出率。将观察组患者根据HbA1c分组,HbA1c水平≤10%的20例患者作为观察1组,HbA1c水平>10%的30例患者作为观察2组,对比观察1组、观察2组血清CP、HbA1c水平以及阳性检出率,Pearson相关性分析血清CP与HbA1c的相关性。对比血清CP、HbA1c联合检测在DM诊断中的灵敏度、特异度。结果 观察组血清CP水平低于对照组,观察组HbA1c水平高于对照组(P<0.05)。观察组CP阴性检出率(72.00%)、HbA1c阳性检出率(74.00%)均高于对照组(0%、2.00%)(P<0.05)。观察2组血清CP水平低于观察1组,观察2组HbA1c水平高于观察1组(P<0.05)。观察2组CP水平(96.67%)、HbA1c阳性检出率(100.00%)均高于观察1组(35.00%、35.00%)(P<0.05)。血清CP与HbA1c呈负相关(P<0.05,r=-0.401)。血清CP联合HbA1c诊断灵敏度(84.70%)、特异度(86.70%)均高于血清CP(73.70%、75.20%)、HbA1c(58.60%、71.40%)单独检测(P<0.05)。结论 血清CP、HbA1c与DM患者病情存在一定相关性,联合检测可提高DM诊断准确率、灵敏度。

Objective To analyze the clinical value of serum CP and HbA1c in the diagnosis of DM.Methods The subjects of this study were 50 patients with DM hospitalized in our hospital from November 2019 to November 2021 as the observation group and 50 healthy persons undergoing outpatient physical examination in the same period as the control group.The serum CP,HbA1c and positive detection rate of the two groups were detected and compared.The patients in the observation group were grouped according to HbA1c 20 patients with HbA1c≤10%were taken as observation group 1 and 30 patients with HbA1c>10%were taken as observation group 2.The serum CP,HbA1c and positive detection rate of observation group 1 and observation group 2 were compared.Pearson correlation analysis was used to analyze the correlation between serum CP and HbA1c.The sensitivity and specificity of combined detection of serum CP andHbA1c in the diagnosis of DM were compared.Results The serum CP in the observation group was lower than that in the control group,and the HbA1c in the observation group was higher than that in the control group(P<0.05).The positive detection rates of CP(72.00%)and HbA1c(74.00%)in the observation groupwere higher than those in the control group(0.00%and 2.00%(P<0.05).SerumCP in observation group 2 was lower than that in observation group 1,and 2 HbA1cin observation group 2 was higher than that in observation group 1(P<0.05).The positive detection rates of 2CP(96.67%)and HbA1c(100.00%)in the observation group were higher than those in the observation group 1(35.00%,35.00%)(P<0.05).There was a negative correlation between serum CP and HbA1c,(P<0.05,r=-0.401).The diagnostic sensitivity(84.70%)and specificity(86.70%)of serum CP combined with HbA1c were higher than those of serum CP(73.70%,75.20%)and HbA1c(58.60%,71.40%)alone(P<0.05).Conclusion There is a certain correlation between serum CP and HbA1c and the condition of DM patients.The combination can improve the accuracy and sensitivity of DMdiagnosis.