自体脂肪移植治疗40例稳定期线状硬斑病疗效回顾分析

Efficacy of autologous fat grafting in the treatment of 40 cases of stable linear scleroderma:a retrospective analysis

目的探讨自体脂肪移植治疗稳定期线状硬斑病的疗效。方法回顾性分析2017年10月至2020年11月于空军军医大学西京皮肤医院进行自体脂肪移植治疗的40例稳定期线状硬斑病患者,其中男22例,女18例,年龄12~36(18.2±4.82)岁。皮损累及前额16例,口周4例,下颌2例,面颊9例,躯干5例,下肢4例,皮肤凹陷缺损量3~24 cm^(3)。随访分析自体脂肪移植后患者的主观满意率、皮损凹陷缺损量的改善情况及不良反应发生率。结果40例患者术后6个月评估,患者皮损凹陷的缺损量均得到明显改善。填充1次后外观改善满意率60%(24/40);35例行2次填充,2次填充后满意率88.6%(31/35);17例行3次填充,3次填充后满意率94.1%(16/17);术后总满意率87.5%(35/40)。3例患者术后填充区出现局部皮肤凹凸不平,2例术后吸脂区出现局部皮肤凹凸不平,术后不良反应发生率12.5%(5/40)。结论自体脂肪移植治疗稳定期线状硬斑病临床效果显著。

Objective To investigate the efficacy of autologous fat grafting in the treatment of stable linear scleroderma.Methods A retrospective analysis was performed on 40 patients with stable linear scleroderma who received autologous fat grafting from October 2017 to November 2020 in the Department of Dermatology,Xijing Hospital,Air Force Medical University.There were 22 males and 18 females,aged 12-36(18.2±4.82)years.Skin lesions involved the forehead in 16 cases,the perioral area in 4,the lower jaw in 2,the cheek in 9,the trunk in 5,and the lower limb in 4,and the size of depressed skin defects was 3-24 cm3.The patients′subjective satisfaction rate,the decrease in the size of depressed skin defects,and the incidence of adverse reactions after autologous fat grafting were analyzed during the follow-up.Results Six months after the grafting,40 patients were followed up and evaluated,and the size of depressed skin defects markedly decreased.The satisfaction rate for appearance improvement after the first grafting was 60%(24/40);35 patients received the second grafting,with a satisfaction rate of 88.6%(31/35);17 received the third grafting,with a satisfaction rate of 94.1%(16/17);the total satisfaction rate was 87.5%(35/40).After the grafting,local skin unevenness was observed in the grafting area in 3 patients,and in the liposuction area in 2.The incidence rate of postoperative adverse reactions was 12.5%(5/40).Conclusion Autologous fat grafting was markedly effective in the treatment of stable linear scleroderma.