肾脏纤维化研究的早期历史回顾(1836-2000)

A narrative review on the research history of renal fibrosis from 1836 to 2000

肾脏纤维化(renal fibrosis,RF)是各种原因引起的慢性肾脏病进展为终末期肾衰竭的主要病理学基础。探讨RF的发生机制是过去近200年肾脏病领域的重大科学问题。科学技术和研究手段的进步为RF研究提供了有力工具,也为RF防治不断提供新的思路。该文简要综述RF研究的历史,从RF早期研究、肾活检技术应用、RF动物模型建立、细胞分子生物技术发展及RF机制探究等方面展开阐述,为未来慢性肾脏病防治的研究提供参考。

Renal fibrosis(RF)is the key pathological feature for the progression of chronic kidney disease to end-stage renal failure.It has been an important scientific issue to understand its mechanism of RF in the field of kidney diseases in the past near two centuries.The progress of science and technology has not only provided a strong tool for RF research,but also given us many new ideas for RF prevention and treatment.The paper briefly reviews the key histories of RF research,with focuses on early studies of renal fibrosis,application of renal biopsy technology,establishment of RF animal models,advancements in cell and molecular biotechnology,and exploration into mechanisms underlying RF,to clarify future directions for chronic kidney disease prevention and treatment research.