精蛋白锌重组赖脯胰岛素联合饮食疗法治疗2型糖尿病的疗效

Efficacy of protamine zinc recombinant insulin lispro combined with diet therapy in patients with type 2 diabetes

目的探讨精蛋白锌重组赖脯胰岛素联合饮食疗法治疗2型糖尿病的疗效。方法选取2019年1月—2020年12月天津市滨海新区杭州道街社区卫生服务中心纳入慢性病健康管理的114例2型糖尿病患者作为研究对象,采用随机数字表法分为观察组与对照组,每组57例。对照组患者采用精蛋白锌重组赖脯胰岛素治疗,观察组患者在对照组基础上联用饮食疗法进行干预,2组患者均持续干预1年。比较2组患者治疗前后的血糖水平、糖化血红蛋白水平及焦虑、抑郁状况。结果2组患者治疗前空腹血糖及餐后2h血糖水平比较,差异均无统计学意义(P>0.05);2组患者治疗后空腹血糖及餐后2h血糖水平均低于治疗前,且观察组患者空腹血糖及餐后2h血糖水平均低于对照组,差异均有统计学意义(P<0.05)。2组患者治疗前糖化血红蛋白水平比较,差异无统计学意义(P>0.05);2组患者治疗后糖化血红蛋白水平低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05)。2组患者治疗前健康问卷抑郁量表(PHQ-9)及广泛性焦虑量表(GAD-7)评分比较,差异无统计学意义(P>0.05);2组患者治疗后PHQ-9及GAD-7评分均低于治疗前,且观察组患者PHQ-9及GAD-7评分均低于对照组,差异均有统计学意义(P<0.05)。结论精蛋白锌重组赖脯胰岛素联合饮食疗法用于2型糖尿病患者,有助于平稳降低血糖及糖化血红蛋白水平,缓解焦虑、抑郁症状,值得临床推广应用。

Objective This paper aims to investigate the treatment outcome of protamine zinc recombinant insulin lispro combined with diet therapy on type 2 diabetes.Methods A total of 114 patients with type 2 diabetes included in the health management of chronic diseases in Hangzhoudao Community Health Service Center from January 2019 to December 2020 were selected as the study participants.They were randomly allocated into the observation group and the control group,with 57 cases in each group.Patients in the control group received protamine zinc recombinant insulin lispro;patients in the observation group received dietary therapy based on the control group.Patients in both groups underwent continuous intervention for 1 year.The blood glucose level,glycosylated hemoglobin level,anxiety and depressive state before and after treatment were compared between the two groups.Results There was no significant difference in fasting blood glucose and 2 h postprandial blood glucose level before treatment between the groups(P>0.05).Fasting blood glucose and 2 h postprandial blood glucose levels after treatment in the two groups declined,and fasting blood glucose and 2 h postprandial blood glucose level in the observation group were lower than those in the control group,with statistical significance(P<0.05).The difference in the glycosylated hemoglobin level before treatment between the two groups was not statistically significant(P>0.05).The glycosylated hemoglobin level after treatment in the two groups was decreased,and the observation group was lower than the control group,with statistical significance(P<0.05).There was no significant difference in the scores of the Patient Health Questionnaire(PHQ-9)and 7-item Generalized Anxiety Disorder Scale(GAD-7)before treatment between the two groups(P>0.05).The scores of PHQ-9 and GAD-7 after treatment in the two groups were decreased,and the scores of PHQ-9 and GAD-7 in the observation group were lower than those in the control group,with statistical significance(P<0.05).Conclusion Protamine zinc recombinant insulin lispro combined with diet therapy for patients with type 2 diabetes is effective in steadily reducing blood glucose and glycosylated hemoglobin levels and relieving anxiety and depressive symptoms.These benefits hold promise for a wider application of this technique clinically.