细颗粒物与神经系统疾病的关联性及机制研究进展

Research progress in relationships and mechanisms between fine particles and nervous system diseases

细颗粒物是空气污染物的重要组分,可对呼吸系统、心血管系统产生显著危害。近年发现,细颗粒物暴露还可对神经系统产生影响,与神经退行性疾病、自闭症谱系障碍等存在关联。该文从流行病学研究基础出发,将细颗粒物进入中枢神经系统的途径、细颗粒物引发氧化应激、炎症反应、神经元突触可塑性变化、血脑屏障损伤等方面进行综述,以期为防控神经系统损伤提供依据。

Fine particulate matter is a major component of air pollutants,which can cause significant harm to the respiratory system and cardiovascular system.In recent years,it has been found that exposure to fine particles can also affect the function of the nervous system,which is associated with the development of neurodegenerative diseases and autism spectrum disorders.Based on the data on epidemiological research,this review summarized the ways fine particles entered the central nervous system,oxidative stress,inflammatory response,changes in neuronal synaptic plasticity,and blood-brain barrier damage caused by fine particles so as to provide data for prevention of injuries to the nervous system.