巨噬细胞对病原体识别与肌动蛋白多聚化的研究进展

Advances in macrophage recognition of pathogens and actin multimerization

巨噬细胞是一种广泛存在于血液和组织的免疫细胞,其能够吞噬和清除胞内寄生虫、细菌、肿瘤细胞以及自身衰老的细胞,在机体的免疫防御中发挥着重要作用。巨噬细胞通过不同的表面受体识别并吞噬病原微生物,释放多种炎症因子,进而保护机体免受各种病原体的侵害。肌动蛋白多聚化在巨噬细胞吞噬病原体过程中至关重要。该文总结了受体介导的巨噬细胞对病原体识别和此过程肌动蛋白多聚化机制的研究进展。

Macrophages are widely distributed in blood and various tissues,which play an important role in host immune defense.Macrophages can phagocytose and clear intracellular parasites,bacteria,tumor cells and host senescent cells.Surface receptors are essential for recognition and phagocytosis of pathogens by macrophages.Meanwhile,a variety of inflammatory cytokines are released in this process.Actin polymerization is indispensable during phagocytosis by macrophages.This paper reviews the research findings on pathogen recognition and phagocytosis mediated by receptors on macrophages.