基质金属蛋白酶-19在肿瘤中生物学特性的研究进展

Research progress in the biological characteristics of matrix metalloproteinase-19 in tumor

基质金属蛋白酶家族(MMPs)是近年学者关注的与肿瘤形成和转移相关的蛋白,细胞在恶性转变过程中可分泌MMPs,不同恶性肿瘤中MMPs的表达具有多样性,MMPs的不同成员也具有不完全相同的生物学特性。基质金属蛋白酶-19(MM P-19)是MMPs的新成员,在细胞恶性转化过程中其分泌量迅速增加,并释放到细胞外,参与肿瘤细胞增殖、黏附、侵袭、迁移及血管生成等生物学过程。主要对MMP-19在肿瘤中生物学特性的研究进展进行综述,以期为探讨肿瘤的发生发展,尤其是研究肿瘤细胞的侵袭和转移提供理论依据。

The matrix metalloproteinases family(MMPs)are proteins related to tumor formation and metastasis that have attracted the attention of scholars in recent years.Tumor cells can secrete MMPs during malignant transformation,and the expression of MMPs in different malignant tumors is diverse,and different members of MMPs do not have exactly the same biological properties.Matrix metalloproteinase-19(MMP-19)is a new member of MMPs whose secretion increases rapidly during the malignant transformation of cells and is released into the extracellular space to participate in biological processes such as proliferation,adhesion,invasion,migration,and angiogenesis of tumor cells.In this paper,the progress of research on the biological properties of MMP-19 in tumors was reviewed to provide a theoretical basis for exploring the development of tumors,especially for studying the invasion and metastasis of tumor cells.