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Janus激酶抑制剂在幼年特发性关节炎相关葡萄膜炎治疗中的研究进展

Research progress of Janus kinase inhibitor in the treatment of Juvenile idiopathic arthritis associated uveitis
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摘要 幼年特发性关节炎相关葡萄膜炎(JIA-U)是儿童常见葡萄膜炎,其并发症最终可导致视力损伤和致盲。目前传统治疗方法及靶向治疗已在JIA-U广泛应用,并有良好的效果。但是仍有部分患者达不到炎症控制和缓解。Janus激酶(JAK)是许多炎症因子的效应通路,JAK抑制剂在其他免疫相关疾病的治疗中也有广泛应用。相比于其他靶向治疗的生物制剂,JAK抑制剂为小分子物质,可通过口服递送,在用药路径上更为便利。和其他类型靶向治疗相似,JAK抑制剂的应用有利于持续的无激素缓解,使患者达到更好的预后。然而,目前JAK抑制剂在JIA-U治疗方面的应用尚无相关指南。深入了解JAK抑制剂治疗JIA-U的作用机制、临床应用及副作用的现状及进展,对JAK抑制剂在临床应用中的推广以及制定应用准则具有重要意义。 Juvenile idiopathic arthritis-associated uveitis(JIA-U)is a common uveitis in children,and its complications can eventually lead to visual impairment and blindness.At present,traditional treatment methods and targeted therapies have been widely used in JIA-U,which has better effect.However,there are still some patients who cannot achieve inflammation control and remission.Janus kinase(JAK)is the effector pathway of many inflammatory factors,and JAK inhibitors(JAKinibs)are also widely used in the treatment of some other immune-related diseases.Compared with other biological agents,JAKinibs is a small molecule substance that can be delivered orally,which is a more convenient medication method.The application of JAKinibs is similar to other types of targeted therapies,which is of great benifit to relieve with continuous hormone-free and a better prognosis.However,there are currently no relevant guidelines for the treatment of JIA-U using JAKinibs.Further understanding of the mechanism,clinical application and side effects of JAKinibs in treatment of JIA-U might is of great significance for popularizing the application of JAKinibs and developping general application guidelines.
作者 佘重阳 卢弘 She Chongyang;Lu Hong(Department of Ophtalmology,Beijing Chao Yang Hospital,Capital Medical University,Beijing 10020,China)
出处 《中华眼科医学杂志(电子版)》 2023年第2期104-108,共5页 Chinese Journal of Ophthalmologic Medicine(Electronic Edition)
基金 国家自然科学基金项目(81471575)。
关键词 幼年特发性关节炎相关葡萄膜炎 Janus激酶抑制剂 临床应用 Junior idiopathic arthritis associated uveitis Janus kinase inhibitors Clinical application
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