2-取代苯并噻吩类化合物的合成研究进展

Progress on the Syntheses of 2-Substituted Benzo[b]thiophenes

2-取代苯并噻吩广泛存在于天然产物中,独特的分子结构使其表现出了较高的药理和生物活性,在药物化学和材料化学方面具有广泛应用。已有多种含苯并噻吩骨架药物用于临床,因此该类化合物具有较高的研究价值。本文结合国内外学者的相关研究,对2-苯基苯并噻吩、2-酰基苯并噻吩和2-氨基苯并噻吩类化合物的合成方法进行综述。

2-substituted benzo[b]thiophenes are is widely found in natural products.Owing to their unique molecular structure,these compounds always exhibit high pharmacological and biological activities and are frequently employed as a key structural unit in pharmaceutical chemistry and material chemistry.A variety of drugs that encompass benzo[b]thiophene structural unit have been used in clinic,addressing their high research value.This paper aimed to summarize the recent developments on the synthetic methods of 2-phenylbenzo[b]thiophenes,2-acetylbenzo[b]thiophenes and 2-aminobenzo[b]thiophenes.