双相抑郁亚综合征和双相缓解期患者生活质量分析

The analysis of quality of life between patients with bipolar depressive subsyndrome and patients with bipolar remission

目的对双相抑郁亚综合征(bipolar depressive subsyndrome,BDS)和双相缓解期(bipolar remission,BRS)患者的生活质量进行分析。方法选取2014年6月至2017年6月在首都医科大学附属北京安定医院就诊的228例BRS患者。对所有患者进行17项汉密尔顿抑郁量表(Hamilton depression rating scale for depression-17 item,HAMD-17)、杨氏躁狂量表(Young mania rating scale,YMRS)及世界卫生组织生存质量测定量表(World Health Organization quality of life scale brief,WHOQOL)评估。根据是否存在BDS分为BDS组和BRS组,比较BDS组和BRS组人口学资料、临床特征及生活质量差异。采用散点图和Spearman相关分析探讨WHOQOL量表不同领域与HAMD-17量表得分之间的相关性。结果BDS组27例,BRS组201例。BDS组首次发作类型以抑郁发作为主,BRS组首次发作类型中抑郁和轻躁狂/躁狂均常见,BDS组的总发作次数少于BRS组,BDS组的HAMD-17总分高于BRS组,差异均有显著性(P<0.05)。根据散点图和线性拟合关系,WHOQOL量表的4个领域与HAMD-17评分呈负相关。生理健康、心理健康、社会关系、周围环境与HAMD-17评分的Spearman相关系数分别为-0.530、-0.455、-0.413、-0.303,差异均有显著性(P<0.001)。BDS组在生理健康、心理健康、社会关系、周围环境4个领域的得分均低于BRS组,差异均有显著性(P<0.05)。结论BDS可导致BRS患者生活质量下降。

Objective To analyze the quality of life between patients with bipolar depression subsyndrome(BDS)group and patients with bipolar remission(BRS)group.Method A total of 228 patients with stable bipolar disorder were included,all of whom were from the Outpatient Department of Beijing Anding Hospital Affiliated to Capital Medical University.All patients were tested with the Hamilton depression rating scale for depression-17 item(HAMD-17),the Young mania rating scale(YMRS)and the World Health Organization quality of life scale brief(WHOQOL).They were divided into BDS group and BRS group according to the bipolar depressive subsyndrome.We compared the differences in demographic data,clinical characteristics and quality of life between BDS group and BRS group and analyzed the correlation between different areas of WHOQOL scale and HAMD score.Result There were significant differences between BDS group and BRS group in the type of first onset,total episodes and the total score of HAMD(P<0.05).There were negative correlations between these four areas of WHOQOL scale and HAMD score(P<0.001).The scores of WHOQOL scale from four areas in BRS patients were significantly higher than those in BDS group(P<0.05).Conclusion Bipolar depressive subsyndrome leads to BRS patients’worse quality of life.