OCT及OCTA应用于非感染性葡萄膜炎的研究进展

Research progress of optical coherence tomography and optical coherence tomography angiography in noninfectious uveitis:a review

非感染性葡萄膜炎(NIU)是一种难以治愈且易复发的眼内炎性疾病,它会导致视网膜及脉络膜发生一过性或永久性的病理改变。为了诊断这些病理改变并进行科学研究,眼科影像学方法是必不可少的工具。增强深度扫描模式的相干光层析成像术(EDI-OCT)、SS-OCT和SS-OCTA是近年来快速发展的眼科影像学方法,在评估黄斑区脉络膜厚度、展示脉络膜全层结构以及监测脉络膜血流循环方面具有显著优势,并且已经被广泛应用于评估包括NIU在内的多种眼病。本文综述了EDI-OCT、SS-OCT和SS-OCTA在评估非感染性中间葡萄膜炎、后葡萄膜炎以及全葡萄膜炎性眼内炎及其他脉络膜并发症方面的研究现状,并对其应用前景进行了展望。

Non-infectious uveitis(NIU)is a challenging type of intraocular inflammatory disease that tends to recur and can be resistant to treatment.It can cause both transient and permanent pathological changes in the retina and choroid.Accurate diagnosis and monitoring of these changes rely heavily on ophthalmic imaging methods.In recent years,the enhanced depth imaging spectral-domain optical coherence tomography(EDI-OCT),swept-source optical coherence tomography(SS-OCT),and swept-source optical coherence tomography angiography(SS-OCTA)have emerged as rapidly evolving ophthalmic imaging techniques that offer significant advantages in evaluating choroidal thickness,displaying the whole choroid,and monitoring choroidal blood flow.This review provides an overview of the current research status of EDI-OCT,SS-OCT,and SS-OCTA in evaluating intraocular inflammation and other choroid-related complications in noninfectious intermediate uveitis,posterior uveitis,and panuveitis,and also highlights their future prospects.