脑缺血后血管内皮细胞对小胶质细胞的调节作用及机制

Pathway and Mechanism of Vascular Endothelial Cells on Microglia after Ischemic Stroke

缺血性卒中目前仍然是人类死亡和长期残疾的主要病因之一。血脑屏障作为大脑与外周之间的重要防线,在维持环境稳态中发挥着重要作用,而血脑屏障的主要成分内皮细胞与神经血管单元其他细胞的相互作用更为关键。缺血性卒中后,血脑屏障渗漏和内皮细胞功能障碍导致血浆成分外渗和循环炎症细胞浸润,进一步激活小胶质细胞等,加剧病灶损伤。本文结合最新的研究进展,对缺血性卒中后内皮细胞对小胶质细胞的作用途径及机制予以综述。

Ischemic stroke remains one of the leading causes of death and long-term disability in humans.As an important barrier between the brain and the periphery,the blood-brain barrier(BBB)plays an important role in maintaining environmental homeostasis.The interaction between endothelial cells,a major component of the BBB,and other cells in the neurovascular unit is particularly critical.After ischemic stroke,BBB leakage and endothelial cell dysfunction lead to extravasation of plasma components and infiltration of circulating inflammatory cells,further activating microglia and aggravating lesion injury.This article will review the pathways and mechanisms of endothelial cells on microglia after ischemic stroke based on the latest research progress.