一种活性肽组合物的人体皮肤抗皱作用及其安全性评价

Anti-wrinkle Effect of an Bioactive Peptide Compound and Its Safety

研究一种活性肽组合物对人体皮肤的抗皱作用,并进行安全性评价。采用人体临床测试,基于研究者评估、仪器测量和受试者自评三个方面对其进行测试评价。结果显示,使用该组合物4、8、12周后,试验侧与使用前基础值比较,皮肤的干燥度、弹性、光泽度、眼下细小皱纹以及鱼尾纹等测试评估指标均有明显改善(P<0.05),且使用时间越长,效果越佳;使用1、4、8周后试验侧与使用前的皮肤含水量比较,有明显提升(P<0.05);使用1、4、8、12周后试验侧与使用前皮肤弹性(R2)值比较,有明显提升(P<0.05);基于图像分析,使用12周后试验侧与使用前鱼尾纹面积比较,有明显缩小(P<0.05)。测试结果表明,该试验产品具有良好的人体抗皱功效。这12周的试验期间,该活性肽组合物未出现1例1级或以上的皮肤不良反应,表明该活性肽组合物具有良好的安全性。

Anti-wrinkle effect of an bioactive peptide compound on human skin and its safety evaluation were studied in this paper.Human clinical tests were used to evaluate it based on three dimensions:researcher evaluation,instrument measurement and subject self-evaluation.The results showed that after using the compound for 4,8 and 12 weeks,the dryness,elasticity,gloss,fine wrinkles and crow’s feet of the skin on the test side were significantly improved compared with the basic values before use(P<0.05),and with the increase of using time,the effect was also better;after 1,4,8 weeks of use,the skin moisture content of the test side was significantly higher than that before use(P<0.05);after 1,4,8,12 weeks of use,the skin elasticity(R2)of the test side was significantly improved compared with that before use(P<0.05).Based on image analysis,the area of crow’s feet on the test side after 12 weeks of use was significantly smaller than that before use(P<0.05).The test results showed that the test product had good anti-wrinkle effect on human body.No case of grade 1 or above skin adverse reactions occurred during the 12 weeks test period,indicating that the bioactive peptide compound had good safety.