免疫信息学在表位疫苗研发中的应用与研究进展

Application of Immunoinformatics in Epitope Vaccine Development

对于表位疫苗的设计,通常是利用免疫信息学工具和相关技术方法对已获取或已知的核苷酸序列和氨基酸序列进行分析,以此确定和预筛选出可能的优势表位,之后通过人工合成或基因工程技术等制备具有优势表位的多肽疫苗。免疫信息学的快速发展使其被成功应用于疫苗学领域,成为开发基于表位多肽疫苗最有效的方法。从免疫信息学在表位疫苗设计中的一般流程及疫苗验证、表位疫苗研发涉及的免疫信息学工具以及免疫信息学在表位疫苗设计中的具体应用等方面进行综述,以期为合理设计和研发有效的表位疫苗提供参考。

Presently,to design epitope vaccines,the research and development process is generally to use computer-aided immunoinformatics tools and related technical methods to analyze acquired or known nucleotide and amino acid sequences to determine and pre-screen out possible dominant epitopes,and then prepare polypeptide vaccines with dominant epitopes through synthetic or genetic engineering techniques.The rapid development of immunoinformatics has been successfully applied to the field of vaccinology,and the immunoinformatics method is the most effective method to develop vaccines based on epitope polypeptide.Immunoinformatics,the general process of immunoinformatics in epitope vaccine design and validation,the immunoinformatics tools involved in the design of epitope vaccines,and the specific application of immunoinformatics in the design of epitope vaccines are reviewed,which will provide reference for reasonable design and development of effective epitope vaccines.