基于PI3K/AKT信号通路的中医药治疗膝骨关节炎研究进展

Research Progress of Traditional Chinese Medicine in the Treatment of Knee Osteoarthritis Based on PI3K/AKT Signaling Pathway

膝骨关节炎是一种好发于中老年人的慢性退行性疾病,目前尚无有效治愈方法。近年来,随着对中医药研究的不断深入与创新,运用中医药方法治疗膝骨关节炎在临床上被广泛应用。中医药具有治疗效果明显,毒副作用小,花费少等优点。在此之前的研究大都从中医辨证的方向阐述中医药对膝骨关节炎的影响,本文将从分子生物及细胞生物学角度来阐述中医药对膝骨关节炎的影响机制。PI3K/AKT信号通路与骨骼密切相关的经典信号通路,其通过炎症、自噬、凋亡等作用调节软骨代谢平衡,在膝骨关节炎的发病过程中发挥重要作用。近年来运用中药单体及复方调控PI3K/AKT信号通路治疗膝骨关节炎已成为当今研究的新热点。现就中医药通过调控PI3K/AKT信号通路防治膝骨关节炎的研究进展做一综述,以期为中医药治疗膝骨关节炎的应用提供参考。

Knee Osteoarthritis(KOA)is a chronic degenerative disease that commonly occurs in middle-aged and elderly people,and there is currently no effective cure.In recent years,with the continuous deepening and innovation of traditional Chinese medicine research,the use of traditional Chinese medicine methods to treat KOA has been widely used in clinical practice.Traditional Chinese medicine has the advantages of obvious therapeutic effect,small toxic and side effects,and low cost.Most of the previous studies have explained the influence of TCM on KOA from the perspective of TCM syndrome differentiation.This paper will explain the mechanism of TCM's influence on KOA from the perspective of molecular biology and cell biology.The PI3K/AKT signaling pathway is a classical signaling pathway closely related to bone.It regulates the metabolic balance of cartilage through inflammation,autophagy,apoptosis,etc.,and plays an important role in the pathogenesis of KOA.In recent years,the use of traditional Chinese medicine monomers and compounds to regulate the PI3K/AKT signaling pathway in the treatment of KOA has become a new research hotspot.This article summarizes the research progress of traditional Chinese medicine on the prevention and treatment of KOA by regulating the PI3K/AKT signaling pathway,in order to provide a reference for the application of traditional Chinese medicine in the treatment of KOA.