摘要
Two recent back-to-back papers published in Nature provide new insights into the structural basis of gasdermin B(GSDMB)targeting by the secreted Shigella virulence effector IpaH7.8,the regulation of GSDMB’s pore-forming pyroptotic activity by alternative splicing,and into the inter-species differences regarding IpaH7.8-mediated inhibition of gasdermin D(GSDMD)activity.
基金
The authors’work is funded by the Medical Faculty of CAU Kiel(to F.A.v.S-H.and B.K.),and a grant from Dr.Werner Jackstädt-Stiftung(to S.K.).S.K.is also supported by the infrastructure of the DFG Cluster of Excellence 2167 Precision Medicine in Chronic Inflammation.The authors would like to thank Maja Lucia Messtorff for creating the figure.
