摘要
Dear Editor,The Coronavirus disease 2019(COVID-19)pandemic has caused over 670 million cases and 6.7 million deaths worldwide,many of which are attributed to cardiovascular complications.Virus-induced endothelial damage,endothelial barrier dysfunction,thrombosis,and cytokine storm are implicated in heart and multi-organ failure.
基金
This work was supported by the British Heart Foundation(BHF)project grant“Targeting the SARS-CoV-2 S-protein binding to the ACE2 receptor to preserve human cardiac pericytes function in COVID-19”(PG/20/10285)(to P.M.and E.A.)
European Commission H2020 CORDIS project COVIRNA(project/id/101016072)(to C.E.and P.K.S.)
BHF Chair award(CH/15/1/31199)(to C.E).In addition,it was supported by a grant from the National Institute for Health Research(NIHR)Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol.E.A.is a postdoctoral researcher supported by the Heart Research UK translational project grant“Targeting pericytes for halting pulmonary hypertension in infants with congenital heart disease”(RG2697/21/23)(to P.M.and E.A.).I.B.is an investigator of the Wellcome Trust(106115/Z/14/Z).
