摘要
Dear Editor,The cell-cell interactions are fundamental mechanisms of differentiating embryonic tissues.1 We aimed to model human embryonic development in stem-cell-derived organoids.We exploited the time series single-cell and spatial transcriptomics to reveal the gene expression landscape in the development of embryonic tissues and their interactions.
基金
We would like to express our gratitude to CPOS at HKUMed for providing technical support in scRNA-seq and FACS,as well as to Cheryl Tam for her assistance with cell sorting and Helen Lockey for her editing services.We also extend our appreciation to the members of Danny Chan,Martin Cheung,Lequan Yu,Joshua Ho,Yuanhua Huang’s labs for their insightful discussions.We are thankful to Center for Translational Stem Cell Biology for the scientific discussion and administrative support.The study is supported by Platform for Technology Fund,RGC ECS 27109921
Seed Fund from the School of Biomedical Sciences,Innovation Technology Commission Funding(Health@InnoHK)
RO1 from National Heart Lung and Blood Institute(HL141805).
