摘要
Dear Editor,Alzheimer’s disease(AD)is the most common neurodegenerative disorder and the No.1 cause of dementia in elderly with no effective treatments.1 The application of stem cell-derived extracellular vesicles(EVs)has emerged as a promising therapeutic strategy for AD.2 EVs are small bilipid layer-enclosed vesicles that display blood-brain barrier(BBB)penetrating ability and similar potency to their parental cells.
基金
We thank Dr.Xinrui Qi,Jie Zhu,Yanyan Zhang,Huiran Wu,Meng Shi,and Jiazhen Qian for technical assistances and proofreading the manuscript.This work was supported in part by research grants from the National Natural Science Foundation of China(No.91949204 and No.81830037 to J.C.Z.,No.81971145 and No.82271477 to X.X.,No.82001116 to G.G.)
Shanghai Health and Wellness Committee,Basic Scientific Research Project,(No.20204Y0031 to Y.W.).
