摘要
T cells are crucial for immune functions to maintain health and prevent disease.T cell development occurs in a stepwise process in the thymus and mainly generates CD4^(+)and CD8^(+)T cell subsets.Upon antigen stimulation,naïve T cells differentiate into CD4^(+)helper and CD8^(+)cytotoxic effector and memory cells,mediating direct killing.
基金
This work was supported by the National Key Research and Development Program of China grants 2021YFA1100702(to B.Z.)
Major International(Regional)Joint Research Project grants 81820108017(to B.Z.)
National Natural Science Foundation of China grants 82271792(to L.S.)
32200727(to L.S.)
Innovation Capability Support Program of Shaanxi 2021TD-38(to B.Z.).
