摘要
The extracellular matrix(ECM)serves as signals that regulate specific cell states in tumor tissues.Increasing evidence suggests that extracellular biomechanical force signals are critical in tumor progression.In this study,we aimed to explore the influence of ECM-derived biomechanical force on breast cancer cell status.Experiments were conducted using 3D collagen,fibrinogen.
基金
This work was supported by following fundings:CAMS Innovation Fund for Medical Sciences(CIFMS)2021-I2M-1-014
the National Natural Science Foundation of China(Grant No.81902578,81974098,8197032158)
the National key research and development program of China(Grant No.2017YFC0908003,2017YFC0908004)
the Project of Health Commission of Sichuan Province(20PJ062)
Post-doctoral Science Research Foundation of Sichuan University(2020SCU12041)
Post-Doctor Research Project,West China Hospital,Sichuan University(2018HXBH084).
