摘要
NO/ROS氧化还原平衡与细胞稳态、功能以及信号转导密切相关。活性氧(ROS)过量产生以及一氧化氮(NO)减少或生物利用度降低等都会造成氧化还原失衡,从而导致不同心血管疾病的发生。NO作为一种重要的气体信号分子,参与维持氧化还原平衡及其相关的生理及病理过程。NO供体化合物及可控递送系统在生物医学领域展现了良好的应用前景。本文拟对胞内NO/ROS氧化还原平衡及其与心血管疾病之间的关系、可控递送NO和(或)清除ROS的生物材料及其在心血管疾病治疗中的应用进行系统总结及展望。
NO/ROS redox balance is closely related to cell homeostasis,function and signal transduction.The overproduction of reactive oxygen species(ROS)or the decrease of nitric oxide(NO)and its bioavailability will cause redox imbalance and lead to a series of cardiovascular diseases.As an important gas signaling molecule,NO is involved in the maintenance of redox balance and related physiological and pathological processes.NO donor compounds and controllable delivery systems show great promise in the biomedical field.In this paper,the intracellular NO/ROS redox balance and its relationship with cardiovascular diseases,biomaterials with NO release and(or)ROS scavenging function and their applications will be summarized and prospected.
作者
孙宇瑶
钱盟
赵强
SUN Yuyao;QIAN Meng;ZHAO Qiang(State Key Laboratory of Medicinal Chemical Biology,College of Life Sciences,Nankai University,Tianjin 300071,China)
出处
《生命的化学》
CAS
2023年第7期1036-1048,共13页
Chemistry of Life
基金
国家重点研发计划-战略性国际科技创新合作重点专项(2018YFE0200500)
国家杰出青年科学基金项目(81925021)。
