免疫微环境与高血压

Immune microenvironment and hypertension

心血管疾病是我国居民的首位死因,而高血压是我国发病人数最多的心血管疾病。免疫系统参与维持各种生理活动,且与血管稳态及心血管疾病密切相关。由免疫细胞和组织局部产生的细胞因子构成免疫微环境调控血管、心脏、肾脏和大脑中枢等器官的功能,参与高血压的发生发展。迄今为止,众多的研究表明,针对免疫微环境中的免疫细胞或细胞因子可以降低血压,具有潜在干预高血压的治疗效应,进而降低心血管疾病风险。本文将对这些研究进行综述,总结免疫微环境如何参与高血压发生发展,并为治疗高血压提供新的临床思路、研发新的治疗策略。

Cardiovascular disease is the first cause of death among Chinese residents,and hypertension is the most common cardiovascular disease in China.The immune system is involved in maintaining various physiological activities and is closely related to vascular homeostasis and cardiovascular disease.The immune microenvironment composed of immune cells and cytokines produced by local tissues regulates the function of blood vessels,heart,kidney and central system,and participates in the occurrence and development of hypertension.To date,numerous studies have shown that targeting immune cells or cytokines in the immune microenvironment can reduce blood pressure and have potential therapeutic effects on hypertension,thereby reducing the risk of cardiovascular disease.This paper will review these studies and summarize how the immune microenvironment is involved in the development of hypertension and provide new clinical ideas and new treatment strategies for the treatment of hypertension.