细胞外基质与肿瘤休眠

Extracellular matrix and tumor dormancy

肿瘤休眠是目前肿瘤研究和治疗的难点之一,治疗后的肿瘤常因肿瘤休眠而发生晚期复发。虽然目前针对肿瘤休眠已有大量的研究,但是肿瘤发生休眠的原因、肿瘤休眠的位置,以及让肿瘤进入休眠的方法等仍是未解之谜。本文介绍了肿瘤休眠研究的历史,以及目前研究者针对肿瘤休眠提出的两种学说,即肿瘤细胞和肿瘤块休眠学说,简述了目前一些肿瘤休眠的研究方法和模型;还总结了目前治疗肿瘤休眠的方案,并分析了肿瘤休眠与细胞外基质的关系,指出通过靶向细胞外基质内容治疗肿瘤休眠的可行性,以期为肿瘤休眠的研究和治疗提供新的思路。

Tumor dormancy presents a significant challenge in both tumor research and treatment,as late recurrence frequently occurs following treatment.Despite extensive research on the topic,the underlying causes,specific locations,and effective methods for inducing tumor dormancy remain unresolved.In this review,we present an overview of the research history of tumor dormancy,including the two theories proposed by researchers,namely the tumor cell and tumor mass dormancy theories.Additionally,current research methods and models of tumor dormancy are briefly discussed.Subsequently,we introduced the current treatment plans for tumor dormancy here,analyzed the relationship between tumor dormancy and extracellular matrix,and pointed out the feasibility of targeting extracellular matrix content to treat tumor dormancy,in order to provide new ideas for the research and treatment of tumor dormancy.