巨噬细胞在肿瘤微环境中的作用及临床应用潜力

Differential role of tumor-associated macrophages in the tumor microenvironment and potential for clinical application

肿瘤微环境(tumor microenvironment,TME)是由多种类型细胞及分泌因子共同组成的肿瘤生长环境。肿瘤相关巨噬细胞(tumor associate macrophage,TAM)是肿瘤组织中浸润的巨噬细胞,约占肿瘤浸润细胞的50%,是TME的重要组成部分。TAM具有支持肿瘤细胞的增殖、侵袭、转移等功能,其浸润程度和功能状态与患者对治疗的响应以及预后关系密切。因此,研究TAM的功能和调控机制,有助于肿瘤治疗新策略的开发。TAMs除了直接影响肿瘤细胞,还可以通过与T淋巴细胞、B淋巴细胞、自然杀伤(natural killer,NK)细胞等细胞的互作,间接影响肿瘤的进展。本文综述了TAM与TME中其他类型细胞之间的相互作用机制及对肿瘤进展的影响,探讨了TAM作为肿瘤治疗靶点的潜力。

TTumor microenvironment(TME)is composed of multiple types of cells and factors.Tumor infiltrating macrophage is termed of tumor associate macrophage(TAM),accounting for about 50%of tumor infiltrating cells,and is an important component of the TME.TAM has been shown to promote the proliferation,invasion,and metastasis of tumor cells,and its infiltration and activation are closely related to the patient's response to treatment and prognosis.Therefore,studying the functions and regulatory mechanisms of TAM can help the development of new strategies for tumor therapy.It has been found that TAM can indirectly affect tumor progression through interactions with T lymphocytes,B lymphocytes,natural killer(NK)cells and other cells,in addition to directly affecting tumor cells.This paper reviews the mechanisms of interaction between TAM and other cell types in TME and their effects on tumor progression,and explores the potential of TAM as tumor therapeutic targets.