Three new sesquiterpenes from roots of Curcuma longa

Objective:To study the chemical constituents from the roots of Curcuma longa.Methods:The structures of the compounds were elucidated based on extensive spectral analysis,including 1D and 2D NMR,MS,UV,and CD analysis.Results:Two new sesquiterpene compounds(1S,2R,5R,7S,8R)-2,8-epoxy-5-hydroxybisabola-3,10-dioen-9-one(1),(1R,2R,5R,7S,8R)-2,8-epoxy-5-hydroxybisabola-3,10-dioen-9-one(2),and a new natural product 6-(4-Hydroxymethylphenyl)-2-methyl-hept-2-ene-4-one(3)together with three known compounds ar-turmerone(4),2-methyl-6-(4-hydroxyphenyl-3-methyl)-2-hepten-4-one(5)and 2-methyl-6-(4-hydroxyphenyl)-2-hepten-4-one(6)were isolated from C.longa root extract with 95%ethanol.Conclusion:In the study,three new compounds were isolated from C.longa,and their absolute configurations were determined.