通过抑制Wnt/β-catenin信号通路延缓肾间质纤维化研究进展

Progress of research on inhibition of Wnt/β-catenin signaling pathway to delay renal interstitial fibrosis

肾间质纤维化是慢性肾脏病进展的重要病理基础,延缓肾间质纤维化的过程可抑制慢性肾脏病发展。在肾间质纤维化动物模型中,使用Wnt抑制剂,可干预Wnt/β-catenin信号通路及其下游靶基因信号传导、肾小管上皮间充质转化(EMT),从而延缓肾间质纤维化进程。Wnt/β-catenin信号通路及其下游靶基因都可能是该通路的调节点,成为延缓肾间质纤维化的潜在目标。本文对通过抑制Wnt/β-catenin信号通路延缓肾间质纤维化的研究进展进行综述。

Renal interstitial fibrosis is an important pathological basis for the progression of chronic kidney disease. Delaying the process of renal interstitial fibrosis may inhibit the progression of chronic kidney disease. In animal models of renal interstitial fibrosis, the use of Wnt inhibitors could interfere with signal transduction of Wnt/β-catenin signaling pathway and its downstream target genes as well as renal tubular epithelial-mesenchymal transition (EMT), thereby delaying the progression of renal interstitial fibrosis. The Wnt/β-catenin signaling pathway and its downstream target genes may all be the potential regulatory molecules, becoming the potential targets to delay renal interstitial fibrosis. This article reviewed the research progress on inhibition of Wnt/β-catenin signaling pathway to delay renal interstitial fibrosis.